The invention relates to a fluid distributor (9, 10) for a column (1) comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; a layer of a resistive medium (12, 22) fixed on one face of the floor (11, 21), the resistive medium being permeable to the fluid; a spacing device (13, 23) inserted between the floor (11, 21) and the layer of resistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.

The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which in use form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same.

The present disclosure relates to scalable processes for extracting, refining and fracationating extracts of natural products, such as plant material and for providing well controlled refined extracts.

Para-xylene is separated from a mixture of xylenes and ethylbenzene by a separation process. An ortho-selective adsorbent is used to reduce the ortho-xylene concentration of the xylenes, prior to contact of the xylenes and ethylbenzene with a para-selective adsorbent. The stream rich in ortho-xylene may be isomerized in the liquid phase to increase the amount of para-xylene therein. The para-xylene-depleted stream may be treated in the vapor phase to remove the ethylbenzene and then subjected to isomerization in the liquid phase to produce a stream having a higher than equilibrium amount of para-xylene.

Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

Embodiments of a method of purifying tetrahydrocannabinol (THC) from a composition containing THC and at least one impurity, e.g., from pesticides, waxes, lipids, pigments, and other cannabinoids, can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The THC products can be used in various pharmaceutical and nutraceutical applications.

Processes for separating a di-carboxylic acid or salt thereof from a mixture containing the di-carboxylic acid or salt thereof and one or more other components are provided. Also separation media useful for these separation processes is provided. In particular, processes for preparing an aldaric acid are described, such as glucaric acid from glucose, which includes separating the aldaric acid from the reaction product. Also, various glucaric acid products are described.

A method of continuous separation of a plasmid from a process feed in an apparatus with at least three chromatography columns packed with separation matrix particles, wherein while one chromatography column is loaded with the process feed, another chromatography column is eluted with an eluent to recover the separated plasmid, and yet another chromatography column is eluted with a further eluent to remove contaminants.

The present invention is directed to a method for the separation of an actinide from another metal. The method comprises the following steps: (a) establishing a non-homogeneous magnetic field across a separation column containing a paramagnetic packing material and (b) providing a fluid containing the actinide and the another metal to the separation column wherein the fluid and the paramagnetic packing material are exposed to the non-homogeneous magnetic field. The non-homogeneous magnetic field is produced by a magnet having a first pole for magnetic interaction with a second pole of the magnet wherein the first pole has a different surface area than the second pole. The non-homogeneous magnetic field has a magnetic field gradient of about 500 lines/cm.sup.2/cm or more. In addition, the present invention is also directed to a method for the separation of one heavy metal from another heavy metal.