A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).

A continuous fixed bed separation system includes a plurality of fixed bed treatment columns, a valve system, and a controller. The valve system provides a continuous flow loop through the plurality of fixed bed treatment columns. The flow loop passes through at least one subset of columns of the plurality of fixed bed treatment columns in parallel. A controller changes the valve system to modify the position of an inlet and an outlet within the flow loop and modify each subset of columns in parallel to include a new subset of columns of the plurality of fixed bed treatment columns in parallel. The new subset of columns partially overlaps with the previous subset of columns. The positions of the valve system are cycled such that each fixed bed treatment column ultimately performs each step of a multi-step separation treatment within the system.

A system for producing steam includes a source of superheated water with superheated water output; a membrane filtration system in fluid communication with the superheated water output and including a membrane filter with a permeate side and an opposing retentate side. The membrane filter includes a separation membrane constructed to reject organic molecules. The system may be used for removing organic compounds, such as anti-corrosion agents or contaminants, from superheated water to produce steam. A method for producing steam includes directing a cross-flow of heated pressurized water including a first concentration of an organic compound across a membrane filter. The membrane filter includes a separation membrane constructed to reject the organic compound; and one or more support layers adjacent the separation membrane. A steam permeate including a second concentration of the organic compound is collected, where the second concentration is lower than the first.

An ion exchanger filter assembly to be flowed through by liquid to be filtered has at least two ion exchanger units, each provided with a housing with an inlet socket and an outlet socket. An inlet-side fluid connection and an outlet-side fluid connection connect the ion exchanger units to each other. The inlet sockets are connected in fluid communication to the inlet-side fluid connection and the outlet sockets to the outlet-side fluid connection. The ion exchanger units are arranged to provide parallel flow along a flow path. Each flow path has a section through the inlet-side fluid connection, a section through the ion exchanger unit, and a section through the outlet-side fluid connection for uniform flow therethrough. Either all flow paths have a same length or have a same flow resistance. A connection pipe for such a filter assembly.

A multi tank water softener system and method in which multiple softeners can be selectively operated in parallel, alternating, or in series in either order. The system reduces risk of legionella and pathogen growth while also reducing salt usage by up to 40%.

The present invention relates to a method performed in a liquid chromatography system, the method comprising: in a first configuration (I), wherein a first separation column is fluidly connected to a separation pump and a detector, supplying a flow from the first separation column towards the detector by means of the separation pump in the first configuration (I); and switching the liquid chromatography system from the first configuration (I) to a second configuration (II), wherein the first separation column is fluidly connected to a second pump and to the detector, and supplying a flow from the first separation column towards the detector by means of the second pump in the second configuration (II). The present invention also relates to a corresponding system, use, computer program product, computer-readable medium and data carrier signal.

The present invention relates to a method in a liquid chromatography system comprising a first separation column, a second separation column, a separation pump upstream the separation columns and a detector downstream the separation columns, the method comprising: detecting a failover activation event relating to one of the separation columns, said separation column being a non-operational column, while the other an operational column; operating the liquid chromatography system in a failover operation mode, after detecting the failover activation event. Operating the liquid chromatography system in the failover operation mode comprises: allowing a fluid connection between the separation pump, the operational column and the detector and preventing a fluid connection between the non-operational column and the detector. The present invention also relates to a system for liquid chromatography.

The invention discloses a bioprocess chromatography column comprising: a) a bed chamber delimited by at least one side wall, a first bed support screen and a second bed support screen; b) a first end wall, secured to or integral with the side wall(s), with a first port fluidically connected via a first distributor to the first bed support screen; c) a second end wall, secured to or integral with the side wall(s), with a second port fluidically connected via a second distributor to the second bed support screen; d) a packing port in a wall; and e) an internal bracing, secured to, or integral with, at least one of the end walls and extending into the bed chamber.

The present disclosure provides methods for analyzing a mixture of proteins using affinity chromatography. In some embodiments, the proteins are heterodimeric bispecific antibodies or antigen-binding fragments thereof. In some embodiments, guanidinium salts are used in the mobile phase of the affinity chromatography. This disclosure provides protein analysis methods that provide superior resolution and lower machine maintenance than other methods.