A method is provided for manufacturing high-purity vitamin E compounds by selectively separating vitamin E compounds such as tocotrienols and tocopherols from oil raw materials such as deodorized distillate, and more specifically, a method is provided, applying to a rich fraction of vitamin E compounds, for obtaining high-purity vitamin E compounds by separating and removing only free fatty acids contained as impurities. The method comprises a process in which a solution containing vitamin E compounds and free fatty acids is placed in contact with a weakly basic anion exchanger, and the free fatty acids are preferentially adsorbed.

An object of the present invention is to provide a method for purifying efficiently and easily a .sup.226Ra-containing solution obtained when .sup.225Ac is produced from a .sup.226Ra target, a method for producing a .sup.226Ra target by using the purified .sup.226Ra-containing solution obtained by the above purification method, and a method for producing .sup.225Ac including these above methods. The method for purifying a .sup.226Ra-containing solution according to the present invention is characterized by including an adsorption step (R1) of allowing .sup.226Ra ions to adsorb onto a carrier having a function of selectively adsorbing divalent cations by bringing a .sup.226Ra-containing solution (a) into contact with the carrier under an alkaline condition; and an elution step (R2) of eluting the .sup.226Ra ions from the carrier under an acidic condition.

Chromatography resins having mixed mode ligands and methods of using such resins are provided.

Chromatography resins having mixed mode ligands and methods of using such resins are provided.

The present invention provides an apparatus and method for producing ultrapure water of extremely high purity that sufficiently meets the requirement for its quality at low production cost with reduced footprint. The apparatus for producing ultrapure water includes a pretreatment system, a primary water purification system, and a subsystem, wherein the primary water purification system includes a high-pressure reverse osmotic membrane separation unit, a degassing unit, an ultraviolet oxidation unit, and an ion-exchange unit in this order.

A method for the separation or depletion of empty AAV capsids from full AAV capsids in an aqueous mixture comprising empty and full AAV capsids, wherein the mixture is contacted with a primary amino groups bearing solid phase surface in a first alkaline milieu whereby (i) full AAV capsids bind to the solid phase surface whereas empty AAV capsids at least partially do not bind to the solid phase surface,
or (ii) both full and empty AAV capsids bind to the solid phase surface, and subsequently the empty AAV capsids are at least partially eluted by means of a second alkaline milieu of a pH value higher than the pH value of the first alkaline milieu, with the proviso that the second alkaline milieu does not elute full AAV capsids from the solid phase surface.

The present invention relates to a single module, flow-electrode apparatus for continuous water desalination, ion separation and selective ion removal and concentration by capacitive deionization, comprising: a first current collector (1), a first compartment (1′) for a flow electrode, a first ion exchange membrane (AEM, CEM), a first liquid-permeable channel (6a) next to the first ion exchange membrane (AEM, CEM), a second ion exchange membrane (CEM, AEM) with a fixed charge opposite to that of the first ion exchange membrane (AEM, CEM) next to the first liquid-permeable channel (6a), a second liquid-permeable channel (6b) next to the second ion exchange membrane (CEM, AEM), a third ion exchange membrane (AEM, CEM) having the same fixed charge as the first ion exchange membrane (AEM, CEM) next to the second liquid-permeable channel (6b), a second compartment (2′) for a flow electrode, and a second current collector (2), wherein a fluid (4) containing suspended conductive particles or a mixture of conductive and non-conductive particles or particles made of a mixture of conductive and non-conductive materials (5) is provided in the first and second compartments (1′, 2′), acting as the flow electrode, as well as a corresponding method.

A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.

A process for purification of antibody or fusion protein through anion exchange chromatography to produce an antibody or fusion protein which is substantially free of at least one of the product-related impurities.

The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations.