The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A manufacturing method of an operation pipe, which use a gel to perform operations such as separation, extraction, purification, elution, recovery, analysis and the like of target components that are biological components such as nucleic acids. More specifically, a manufacturing method of an operation pipe, with which it is possible to perform operations such as separation, extraction, purification, elution, recovery, analysis and the like of target components in a sealable pipe by operating magnetic particles in the pipe under a magnetic field from outside of the pipe.

Systems, methods, and cartridges taught herein improve chromatographic performance in electrospray systems that feature chromatographic columns having a conductive or semiconductive stationary phase by electrically connecting a fluid junction located upstream of the chromatographic column to a fluid union located downstream of the chromatographic column using an electrical conductor. The electrical conductor creates a voltage equipotential between a first end of the chromatographic column and a second end of the chromatographic column that neutralizes current flow through the chromatographic column. Accurate electrospray current measurements are enabled while post-column peak dispersion and repeatable retention time are achieved.

The present disclosure relates to the detection of analytes in high volumetric flow applications. Particular embodiments relate to the use of fluorescence polarization/anisotropy based for detection of analytes in a flow cell. In one testing format, an analyte of interest is probed with reagents containing fluorescent labeled recognition elements. When present in a sample or portion of a sample, thee labeled analyte produces a shift in fluorescence polarization/anisotropy/intensity/lifetime as the output signal following the binding of the recognition elements to the analytes.

The invention relates to a method for preparing a magnetic mesoporous silica-based (MMS) material, said method comprising the steps of: i) functionalising the silanol (SiOH) groups of a mesoporous silica-based material by covalently grafting a ligand (L) comprising, at at least one end, a zwitterionic group of formula (I), in particular which is capable of complexing superparamagnetic particles: where n is an integer equal to 3 or 4; ii) incorporating superparamagnetic ferrite (MFe.sub.2O.sub.4NP) particles within the mesoporous material, by means of which a magnetic mesoporous silica-based (MMS) material is obtained.

A device (100, 100, 100) for separating an analyte (200) from other components in an electrolytic solution. The device comprises a housing (114, 115, 116, 117, 118, 119) provided with a solution inlet (104) and a solution outlet (105); a working electrode (101) arranged in the housing such that an electrolytic solution arranged to flow (F) from the inlet to the outlet contacts at least a portion of the working electrode; a counter electrode (102) arranged in the housing (114, 115, 116, 117, 118, 119). At least a portion of a surface of the working electrode (101) is provided with a polyelectrolytic coating (111), the polyelectrolytic coating (111) being arranged to upon application of a potential difference between the working electrode (101) and the counter electrode (102) switch between a first and second state, wherein in the first state an analyte (200) is captured in the polyelectrolytic coating (111) and in the second state a captured analyte (200) is released from the polyelectrolytic coating (111).

The invention relates to membranes for separation, removal, and/or concentration purposes. The object of the invention is the simple and reliable adsorption of the molecules and to simplify the desorption of target molecules that are adsorbed and chromatographically bonded on membranes, preferably without the addition of substances with a high ion content, such as acids, alkalis or salts. The object of the invention is also to develop a value that can be easily measured, which allows for an indication of the current and/or remaining binding capacity of the membrane during the adsorption process and/or the control thereof. The adsorption takes place on a charged membrane and desorption is achieved using physical, electromagnetic and/or the generation of electrical fields. This is carried out with a thin metal layer being applied to one or both sides of a positively or negatively charged membrane and a voltage is applied for desorption.

The present disclosure relates to a process, a system and a use for removing micropollutants (1) in liquid (2). The process comprises providing liquid (2) to a container (3) adapted to hold a liquid and/or a gas, providing magnetic activated carbon (4), mixing it, separating the magnetic activated carbon (4) using a magnetic separator (5), removing between 1 and 100% of the separated used magnetic activated carbon (4), removing the liquid (2), providing new liquid (2) to the container (3), providing the used magnetic activated carbon (4) to the container (3), adding between 1 and 100% of unused magnetic activated carbon (4), repeating the mixing and separation steps at least one time. The process allows for control of several parameters, such as the flow rate of the liquid, dosage of MAC and ratio used/unused MAC required to remove micropollutants from the liquid.

The present invention is directed to methods for using particles (e.g, microparticulate, nanoparticulate; magnetic, non-magnetic) comprising surfaces comprising capture moieties as described herein, to remove an interference as described herein, or enrich biomarkers, prior to a diagnostic test.