The present invention relates to a method for producing a porous membrane, the method being characterized in that a solvent system comprising 2-pyrrolidone and N-alkyl-2-pyrrolidone is used, wherein the content ratio of 2-pyrrolidone to N-alkyl-2-pyrrolidone in the solvent system is from 90%:10% to 10%:90%, based on mass %, and wherein N-alkyl-2-pyrrolidone is N-propyl-2-pyrrolidone and/or N-butyl-2-pyrrolidone. Furthermore, the present invention relates to a porous membrane obtainable by said method. Moreover, the present invention relates to the use of a specific solvent system for the production of a porous membrane.

The present invention provides a method for manufacturing a porous membrane having high water permeability and hydrophilicity, which is not easily affected by a treatment such as washing, the method including: preparing, as a substrate, a membrane having a plurality of pores, which includes a water-insoluble resin such as polysulfone and a water-soluble resin including a monomer unit of polyvinylpyrrolidone or a monomer unit of polyvinyl alcohol; and irradiating the substrate with an electron beam in the presence of an aqueous solvent to crosslink at least a part of the water-soluble resin.

The present disclosure relates to a membrane prepared from a blend comprising i) a polysulfone, polyether sulf one or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and chon-droitin. Optionally the coating further comprises heparin. The disclosure further relates to a process for producing the coated membrane, a method of increasing the selectivity of a membrane, and to a filtration/diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

This invention provides a polymeric separation membrane that has excellent durable antibacterial effect and stain resistance, and a preparation method thereof. The polymeric separation membrane can be widely applied for water treatment, which belongs to the field of water treatment and membrane separation science and technology. The polymeric separation membrane containing quaternary ammonium salt is prepared by the immersion precipitation phase inversion method, using quaternary ammonium salt mixed with polymer and additives. This modification method effectively improves the antibacterial and antifouling ability of the polymeric separation membrane prolongs the service life of membranes and significantly inhibits the reproduction of bacterial and microbial. The preparation method has the advantages of simple process, easy operation, easy for promotion, and also avoids expensive equipment. The polymeric separation membrane has great antibacterial ability and stain resistance, therefore, it has potential application in the field of water treatment.

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

A separation membrane includes a membrane comprising a polymer, characterized in that a functional layer is formed on the surface in one side of the membrane, the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface of the preceding functional layer is 0.1% (by atomic number) or more but not more than 10 (% by atomic number), and the peak area percentage of carbon derived from ester group measured by the electron spectroscopy for chemical analysis (ESCA) on the surface opposite to the functional layer is not more than 10 (% by atomic number). A separation membrane module suffering from little sticking of organic matters, proteins, platelets and so on is provided with the separation membrane as a built-in membrane.

A method for preparing a homogeneous braid-reinforced (HMR) PPTA hollow fiber membrane combines PPTA hollow tubular braids with PPTA surface separation layer. The method includes following steps of: (1) preparing the PPTA hollow tubular braids, wherein the PPTA hollow tubular braids which are made from PPTA filament yarns are woven by a two-dimensional braided method, the outer diameter of the PPTA tubular braids is 1-2 mm; (2) preparing the PPTA casting solution as the surface separation layer, wherein the 1-3 wt % PPTA resin, 0-2 wt % inorganic particles and 10-20 wt % pore-forming agents are mixed into 75-89% inorganic acid solvent, stirred for 1-3 hours at 70 C.-90 C. to form homogeneous and transparent casting solution; and (3) preparing reinforced PPTA hollow fiber membrane, wherein the casting solution as the surface separation layer is evenly coated on the surfaces of the PPTA hollow tubular braids through spinneret, and they are immersed in a coagulation bath for solidified formation.

Provided are a lined hollow fiber membrane (HFM) with a sandwich structure, and a preparation method and use thereof. In the lined HFM with a sandwich structure, a membrane structure of the lined HFM includes an inner PVDF layer, a braided liner layer, and an outer PVDF layer in sequence from inside to outside.

The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS: (1) the minimum value of normalized intensity of the ion signal attributed to the biocompatible polymer in the coarse layer is 0.15 times or more of the maximum value, and (2) the normalized average intensity of the ion signal attributed to the biocompatible polymer in the dense layer is 2.0 times or more of the normalized average intensity of the ion signal attributed to carboxylic acid in the coarse layer.

The invention discloses a dope solution for membrane fabrication comprising a blend of TEP with NMP as a solvent system in a process to make PVDF membranes, where PVDF resin comprises a homopolymer resin, or a copolymer of VDF and at least one of hexafluoropropylene, trifluoroethylene, chlorotrifluoroethylene, or a tetrafluoropropene.