A flow-path-regulating, dip-tube device is an adaptable, scalable, flow-through performance enhancement to any vessel-type, reaction containment apparatus. This apparatus is embodied as a reconfigurable, quasi-dip tube which modularly improves reaction processing, performance, and efficiency. This apparatus increases operational flexibility, adaptable design, and vastly improves efficiencies and flow predictability of vessel-type reaction containers by retrofitting them with benefits of tubular reaction-containment configurations. Internally, the dip-tube device defines one or more closely spaced, functional voids which operate as fluid channels that can be configured in various geometric or topologic arrangements. The dip-tube apparatus is widely scalable, provides high thermodynamic efficiency, manufacturing simplicity, and affordability for varied operations through additive manufacturing, and has a compact physical footprint conformally fitted within a parent container.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

The present disclosure provides a method and a system for denitrogenation combustion and CO.sub.2 capture and utilization in a gas boiler. The method is implemented by the system for denitrogenation combustion and CO.sub.2 capture and utilization in the gas boiler, and comprises: after circulating flue gas is discharged from a gas boiler, introducing the circulating flue gas into a gas heat exchanger to perform heat exchange with natural gas, hydrogen, and carbon-based denitrogenation gas; introducing the circulating flue gas after heat exchange into a flue gas dehydration device to perform dehydration; introducing a first portion of the circulating flue gas after the heat exchange and dehydration into a blower through the flue gas dehydration device to be pressurized by the blower and introduced into a carbon-based denitrogenation gas mixer; preparing the carbon-based denitrogenation gas by mixing oxygen and the circulating flue gas using the carbon-based denitrogenation gas mixer for combustion for the gas boiler; and introducing a second portion of the circulating flue gas after heat exchange and dehydration into a CO.sub.2 recovery device to perform purification and deoxygenation through the flue gas dehydration device to obtain a CO.sub.2 product, and pressurizing and transmitting the CO.sub.2 product to a CO.sub.2 utilization device through a CO.sub.2 compressor.

A closed-system flow cell system featuring an encasement with an inner cavity adapted to hold a slide and form a channel atop the slide. The encasement comprises a groove pattern within the channel, wherein the groove pattern provides a chaotic advection regime to fluid within the channel. The flow cell system helps enhance fluid mixing and prevent reagent evaporation and drying out of the tissue.

Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

The present disclosure provides a method and a system for denitrogenation combustion and CO.sub.2 capture and utilization in a gas boiler. The method is implemented by the system for denitrogenation combustion and CO.sub.2 capture and utilization in the gas boiler, and comprises: after circulating flue gas is discharged from a gas boiler, introducing the circulating flue gas into a gas heat exchanger to perform heat exchange with natural gas, hydrogen, and carbon-based denitrogenation gas; introducing the circulating flue gas after heat exchange into a flue gas dehydration device to perform dehydration; introducing a first portion of the circulating flue gas after the heat exchange and dehydration into a blower through the flue gas dehydration device to be pressurized by the blower and introduced into a carbon-based denitrogenation gas mixer; preparing the carbon-based denitrogenation gas by mixing oxygen and the circulating flue gas using the carbon-based denitrogenation gas mixer for combustion for the gas boiler; and introducing a second portion of the circulating flue gas after heat exchange and dehydration into a CO.sub.2 recovery device to perform purification and deoxygenation through the flue gas dehydration device to obtain a CO.sub.2 product, and pressurizing and transmitting the CO.sub.2 product to a CO.sub.2 utilization device through a CO.sub.2 compressor.

Embodiments of the present invention relate to a mixing apparatus. Particularly, embodiments of the present invention provide a mixing apparatus for mixing fluid components such as phosgene and amine during a highly reactive chemical reaction. One embodiment provides a mixing conduit comprising a cylindrical sidewall defining an inner volume, wherein one or more jets are formed through the cylindrical sidewalls and connect to the inner volume and one or more flow obstructions disposed in the inner volume, wherein each flow obstruction is positioned upstream from an associated aperture.

The present disclosure is directed towards a disposable microfluidic cartridge configured for use in a system for the small scale production of nanoparticles used in scientific research or therapeutic applications. The system can be used to produce a wide variety of nanoparticles, including but not limited to lipid and polymer nanoparticles, carrying a variety of payloads. The system provides for a simple workflow which in certain embodiments can be used to produce a sterile product.

Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.