This disclosure relates to a static mixer element comprising an elongated integral scaffold, wherein the scaffold comprises plurality of polytope projections in (i) a radially or axially arranged network or (ii) a spiral ribbon of polytope projections to define a plurality of passages configured for mixing one or more fluidic reactants during flow and reaction thereof through the mixer, wherein the static mixer element comprises at least one elongated support member, wherein at least a portion of the plurality of projections are in connection with the elongated support member.

A static mixer for use with biopharmaceutical compositions includes a shell and a core. The shell defines a flow channel therethrough. The shell is formed as a lattice structure that defines a plurality of voids in fluid communication with the flow channel. The core is disposed within the flow channel of the shell. The core is configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the flow channel. The first fluid or the second fluid is a biopharmaceutical composition.