A mixing device for mixing exhaust gas from a combustion engine of a vehicle with a solution for lowering the content of nitrogen oxides in the exhaust gas includes a casing with an exhaust inlet, an exhaust outlet, and a corner region in which an exhaust gas flow is diverted toward the exhaust outlet. The corner region has an opening for a dosing unit. A flow guide is arranged within the casing. The flow guide is configured to divide a total of the exhaust gas flow into a first exhaust gas stream and a second exhaust gas stream. A gap for the second exhaust gas stream is formed between the flow guide and a side wall of the casing. In the side wall the opening for the dosing unit is located. An end region of the flow guide is arranged upstream of the opening for the dosing unit.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

The disclosure provides for a lab-on-a-chip (LOC) device and a method of fabrication thereof. Additionally, a system and a method for point of care testing of multiple biomarkers such as glucose, cholesterol, creatinine, uric acid, and bilirubin is provided. The microfluidic assembly consists of three layers in which the top and the middle layers are made up of polydimethylsiloxane (PDMS) and the bottom layer with polyethylene terephthalate (PET). The device integrates screen printed non-enzymatic electrochemical sensors in the bottom layer for simultaneous detection of glucose, cholesterol, creatinine, uric acid, and bilirubin. A hand held potentiostat with readout enables readout for the point of care application of integrated sensing device. The device developed has potential to revamp healthcare by providing access to affordable technology for better management a diabetes and related complications at every door step.

An assay cartridge for mixing a test sample and reagent for diagnostic purposes, and method of using the same. The assay cartridge includes a housing, an injection port for receiving the test sample (whole blood), a filtration membrane for separating plasma from the sample, a section for receipt of reagent, and one or more sets of valves provided in the housing. Each valve is configured for movement between an open position and a closed position. Metering chambers are provided in the housing for receiving separated plasma and the reagent therein. A port is fluidly connected to each metering chamber and uses to draw air from or deliver pressurized fluid into the housing. Mixing channels are provided in the housing and selectively connected to the metering chambers for mixing the separated plasma and reagent into a substantially homogeneous mixture. The homogeneous mixture is delivered out of the housing through output ports.

A vortexing chamber, including: a chamber housing having a hollow channel, a first end and a second end; and one or more structural impediment objects having a substantially spherical, cubic, rectangular, cylindrical, polyhedron, tetrahedron, or irregular shape; where the objects are housed within the hollow channel, configured to mix a liquid and gas (for example, oxygen or nitrogen) when a liquid and gas pass through the vortexing chamber. The structural impediment objects can provide turbulence and dispersion when a liquid and gas are passed through the vortexing chamber at a high velocity, resulting in micro-bubbles or nano-bubbles suspended in a liquid and gas mixture.

Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.

A mixing device includes a mixing cavity having a partially open wall and a closed wall. In certain examples, the partially open wall and the closed wall are two separately formed pieces. A downstream side of the mixing device is shaped so as to define a helicoidal groove for circumferentially guiding gas from an outlet opening of the mixing cavity in a downstream direction. An injector sprays reactant into the mixing cavity.

Provided is a nano-micro bubble generator according to one aspect of the present invention, the nano-micro bubble generator including: a housing which a fluid flows into and out of; a plurality of rotors rotatably coupled to the inside of the housing; and a plurality of stators fixed to the inside of the housing and alternately arranged with the plurality of rotors, wherein at least one of the rotors and the stators has a mesh-like structure in which a plurality of flow passages of the fluid are arranged in a lattice form, and the rotors and the stators are arranged to be adjacent to each other so as to generate a collision, friction, and cavitation due to rotation of the rotors in the fluid flowing through the flow passages, thereby generating at least one of nano bubbles and micro bubbles in the fluid.

Disclosed herein is a cell culture device and its applications of creating gradient of chemicals or gradient of cells to mimic the in vivo physiological conditions of homeostasis.

A mixing connector includes an intake passage, an EGR passage that fetches a portion of exhaust gas exhausted from an engine body to use as EGR gas, and that returns the EGR gas to the intake passage, and a merging section that connects the EGR passage to the intake passage so that longitudinal directions of the intake passage and the EGR passage intersect each other. An upstream side region located on an inlet port side of the intake passage from the merging section on an opposite wall surface configuring an inner surface of the intake passage and located on a side opposite to the merging section includes a first wall surface and a second wall surface which are sequentially arranged at an interval from the merging section side toward the inlet port, and a third wall surface projecting inward of the first wall surface between the first and second wall surfaces.