Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

A diffusion system comprising an upper unit and a lower unit. The upper unit comprises a series of tubing that is situated so as to effectuate collision of the fluid and air molecules. The upper unit uses vortex winding and unwinding and pressure gradients to avoid gas and liquid separation to accomplish successful collisions between a gas and a liquid. The lower unit comprises a filtering system, liquid intake system, air intake system, and submersible liquid transportation system.

System for dispensing a makeup product, having a dispenser (11) that receives at least two cartridges (30), each one having a reservoir containing a base product, the latter leaving the cartridge via an outlet channel (52) of the cartridge, this outlet channel opening out at the outside of the dispenser or near the external surface thereof.

A microfluidic apparatus includes a substrate defining a microchannel having inlet and an outlet defining a length of the microchannel. The microchannel has a main channel extending from the inlet to the outlet, and a plurality of side cavities extending from the main channel. The cavities are in fluid communication with the main channel. A method includes introducing a sample into the microchannel through the inlet to fill the entire microchannel, and then introducing a solvent into the microchannel through the inlet at a controlled flow rate and inlet pressure. A developed solvent front then moves along the main channel from the inlet to the outlet while displacing the sample in the main channel. Images of the microchannel are acquired as the front moves, and a miscibility condition is determined based on the images.

A system for dispensing at least one makeup product, including a cup and a dispenser for filling the cup from the bottom with at least one product, the cup being secured to the dispenser at least while it is being filled with said product. The method for dispensing and evaluating makeup, including the steps of: allowing a video link to be established, for example over the Internet, from a camera at a first site to a second site, allowing the second site to operate either directly or indirectly a dispenser of such a dispensing system, present at the first site, this dispenser making it possible to vary the colour of mixture dispensed, and allowing a person present at the first site to apply the mixture dispensed and to send to the second site a corresponding image, so as to receive in return information relating to the result of the makeup.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

In one embodiment, a selective plane illumination microscopy system for capturing light emitted by an illuminated specimen includes a specimen stage having a top surface adapted to support a specimen holder and an opening adapted to provide access to a bottom of the holder, and a selective plane illumination microscopy optical system positioned beneath the stage, the optical system including an excitation objective, a detection objective, and an open-top, hollow prism that is adapted to contain a quid, wherein the prism is positioned within the opening of the stage and optical axes of the objectives are aligned with the prism such that the axes pass through the prism and intersect at a position near the top surface of the specimen stage.

An exhaust system for a diesel engine, includes an exhaust passage adapted to be attached to the diesel engine. A diesel oxidation catalyst is provided in the exhaust passage along with a selective catalyst reduction device disposed downstream from the diesel oxidation catalyst. A diesel exhaust fluid mixing system includes a diesel exhaust fluid injection nozzle and a mixing device defining a single inlet opening and a single outlet opening connected to one another by a partial spiral flow passage. The diesel exhaust fluid injection nozzle injects diesel exhaust fluid directly into the inlet opening of the partial spiral flow passage.