Carbonation apparatus is provided for carbonating a mixed input flow of pressurized and refrigerated carbon dioxide and water. A first cartridge is disposed within the carbonation chamber, defining a porous micromesh net in fluid communication with the input flow and a central cavity in fluid communication with the carbonation chamber output port. The micromesh net is configured to break up chains of water molecules passing through the net, to enhance bonding between the water and carbon dioxide molecules within the cartridge. The net also responds to the flow of water and carbon dioxide molecules impacting and passing through the net by generating a passive polarizing field that has a polarizing influence on the water molecules to further enhance. Beads may be provided within the cartridge for capturing and stabilizing carbon dioxide molecules to yet further enhance bonding between the water and the carbon dioxide molecules.

Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly (100) includes, inter alia, a housing (10), an inlet fitting (40), and a mixer cartridge assembly (60). The housing (10) has a fluid receiving section (16) and a fluid discharge section (18) with an outlet (20) formed therein. A central bore (22) extends between the fluid receiving section (16) and fluid discharge section (18). An inlet fitting (40) is engaged with the housing (10) and has first (42) and second (44) fluid ports formed therein that extend from the fitting exterior to the fluid receiving section (16) of the housing (10). A mixer cartridge assembly (60) is disposed within the central bore (22) of the housing (10) and is positioned between the inlet fitting (40) and the downstream end portion of the housing (10). The mixer cartridge assembly (60) includes a body portion (64), a plurality of spheres disposed within a central mixing chamber (62) formed in the body portion (64), and mechanism for retaining the spheres in the mixing chamber (62).

A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).

The apparatus and methods of the present invention are of use for the production of emulsion-based microparticles containing a biological or chemical agent. In particular, the apparatus provides a vessel; packing material situated inside such vessel and may further provide material capable of insertion into both ends of said vessel for enclosure of the packing material. In a particular embodiment, the apparatus is a packed bed apparatus. The methods include production of emulsion based microparticles containing a biological or chemical agent. The usefulness of the present invention is that the apparatus and methods of the present invention provide for a low-shear, non-turbulent, production of emulsion-based microparticles that provides a narrow, reproducible, particle size distribution, capable of use with both large and small volumes that is capable of being conveniently scaled up while providing predictable emulsion properties.

A handheld device for mixing a liquid and a gas to form foam before a treatment procedure comprises: an inlet for letting a liquid enter the device, the inlet adapted for attachment to a syringe containing the liquid, an outlet for letting a formed foam exit the device, a chamber containing a gas, the chamber comprising the inlet and outlet, at least one agitation element disposed in the chamber, the at least one agitation element is arranged for independent movement in at least one degree of freedom, the at least one agitation element sized and shaped to mechanically agitate liquid flowing past the at least one agitation element, the liquid flowing in an overall inlet-to-outlet direction, the agitation being sufficient for the at least some of the liquid to mix with the gas to produce the formed foam; the device is dimensioned for holding in one hand.

Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. Disclosed herein are columns for receiving a packing material that permits fluid flow through the column. The columns have a periphery that defines an interior cavity in fluid communication with inlets and outlets of the column. Disclosed herein is a method of preparing an emulsion that includes (1) forming a first phase typically containing an organic solvent, a polymer, and one or more biologically active agents and/or chemicals; (2) forming a second phase typically containing water as the second solvent, an emulsion stabilizer and optionally a solvent; and (3) passing the first and the second phases through the column to form a water in oil type emulsion.

Embodiments of the present technology may include a system for forming an emulsion. The system may include a coiled tube. The coiled tube may have a first end and a second end. The second end may be located at a position higher than the position of the first end. The system may also include a plurality of beads disposed within the coiled tube. The system may further include a first inlet fluidly connected to the coiled tube. The first inlet may be configured to deliver a first fluid to the first end before the second end. In addition, the system may include a second inlet fluidly connected to the coiled tube. The second inlet may be configured to deliver a second fluid to the first end before the second end.

The present disclosure relates to a mixer device having a housing including at least first and second adjacent mixing cells (2, 3), each cell (2, 3) including a fluid inlet opening (21, 31) and a fluid outlet opening (22, 32), the inlet opening being offset from the outlet opening so that the axis of the inlet opening is parallel to the axis of the outlet opening, the outlet opening of the first cell being connected to the inlet opening of the second cell via a connecting channel.

An apparatus for preparing foam for incorporation into cementitious slurry comprises a conduit having an inlet for receiving a gas feed and a surfactant feed, and an outlet for allowing the exit of foam. The conduit houses a porous plug that provides a partial barrier to fluid flow along the conduit, the plug comprising a plurality of particles that are packed in a regular array and that define a three-dimensional network of pores extending therebetween. The apparatus comprises a resilient component located between the plug and the conduit.

The present invention relates a method for incubating liquids, to a method for preparing a biopharmaceutical drug, and to a device for the preparation of a biopharmaceutical drug.