This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

The invention relates to a mixing system, in particular a bioreactor and/or a pallet tank, for mixing a fluid and/or solid, having a container (4), wherein the fluid and/or the solid and a rotatable stirring element (3) for mixing the fluid and/or the solid are arranged in the interior of the container (4). The mixing system furthermore has a mixing device (1) for receiving the container (4) and a drive device (2) for driving the stirring element (3). The drive device (2) comprises a stator (20) of a three-phase machine (10; 11), the stirring element (3) comprises a rotor (30) of the three-phase machine (10; 11), and the rotor (30) has at least one permanent magnet (31; 31) and/or at least one short circuit rotor.

A feed mixer truck for mixing feed and for discharging mixed feed into an elongated feed bunk. The engine of the truck is mechanically connected to three hydraulic pumps which are hydraulically connected to a hydraulic motor for driving the drive wheels of the truck, which are hydraulically connected to a hydraulic motor for operating the feed mixer augers, and which are hydraulically connected to a hydraulic motor which operates a feed discharge assembly. A control is electrically connected to the motors to control the operation thereof.

This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

A method for automatic speed control of an orbital shaker device to determine one of at least two stacked orbital shaker devices operating in an out of balance condition includes the steps of a) Starting the first orbital shaker device, b) Accelerating the first orbital shaker device, and c) Determining a vibration level of the first orbital shaker device, and d) Automatically decreasing a speed of the first orbital shaker device if the vibration level determined in step c) exceeds a predefined first threshold, wherein the steps a) to d) are additionally executed for a second orbital shaker device independently from the first orbital shaker device.

Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.

The present disclosure refers to a filling machine and to a method for filling a foodstuff which comprises at least two components to be mixed, particularly for sausage production. The foodstuff may be filled into a filling hopper of the filling machine and thoroughly mixed with a mixing cam. The mixing cam may be driven via its own drive at different speeds according to a specific speed profile while the foodstuff is conveyed out of the lower portion of the filling hopper via a conveying mechanism and is filled via a filling unit.

The present invention relates to a large-scale magnetic purification system, including: a liquid storage apparatus, capable of being connected to a liquid source and a waste liquid barrel through a liquid path system; a stirring system mounted above the liquid storage apparatus, where a stirring paddle of the stirring system is inserted into the liquid storage apparatus for stirring; magnets mounted around the liquid storage apparatus; a magnet actuating mechanism for manipulating the magnets to move away from or close to the liquid storage apparatus; and a control system, connected to the liquid path system, the magnet actuating mechanism, and the stirring system and controlling the liquid path system, the magnet actuating mechanism, and the stirring system.

A mixer nozzle assembly for mixing fluid introduced into a tank having a tank volume therein. The mixer nozzle assembly includes a stationary body and a rotatable body mounted on the stationary body for rotation about an axis in a predetermined direction. The fluid flows through the stationary body to the rotatable body and exits into the tank volume via one or more outlet apertures, thereby causing the rotatable body to rotate in the predetermined direction about the axis. The mixer nozzle assembly also includes a governor subassembly for controlling a speed of rotation of the rotatable body in the predetermined direction about the axis.

Systems and methods that implement a GUI functional block that allows a user to specify a compounding formula for a composition, an ingredient validation functional block configured for receiving a code on a container holding a first ingredient, consulting a database to derive a formulation ingredient to be used in preparing the composition, determining if the first ingredient matches the formulation ingredient, a planetary mixer control functional block configured for consulting the database arrangement at least partly on a basis of the specified compounding formula to determine mixing parameters for a planetary mixer that are associated with the specified compounding formula, causing a motor assembly of the planetary mixer to apply superimposed rotation and revolution movements to a container in accordance with the mixing parameters determined from the consulting, preventing operation of the motor assembly if the determining step fails to match the first ingredient to the formulation ingredient.