The present invention is directed to a process for preparing Substituted Indole Compounds of Formula (I): wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. These indole compounds are useful as synthetic intermediates for making inhibitors of HCV NS5A.

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Metal-inorganic frameworks (“MIFs”) having enhanced adsorption capabilities to hydrogen, CO, CO.sub.2, hydrocarbons, and a variety of other guest molecules are disclosed. All linkers in the MIFs contain metal complexes, comprising metal atoms and inorganic or organic ligands, instead of only organic ligands as linkers in metal-organic frameworks (MOFs). Compared to their MOF counterparts, MIFs with carbon-free or carbon-deficient chemical structure are expected to possess enhanced thermal stability, higher catalytic activity, and higher gas affinity and selectivity.

A Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a Cu(I)-Catalyzed Azide-Alkyne Cycloaddition reaction, comprising: combining in a solution an alkyne-tagged component, an azide-tagged component and a Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core; filtering the solution through a solid phase extraction filter to remove Cu(I)-ligand catalyst and/or excess ligand.

Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.

Processes for producing an α,β-unsaturated carboxylic acid, such as acrylic acid, or a salt thereof, using solid promoters are disclosed. The solid promoters can be certain solid oxides, mixed oxides, and clays, illustrative examples of which can include alumina, zirconia, magnesia, magnesium aluminate, sepiolite, and similar materials.

A process for catalyzed reaction of CO and H.sub.2 into methanol includes the step of reacting the CO and H.sub.2 with a catalyst comprising a transition metal and at least one Lewis basic ligand together with at least one nucleophilic promoter so as to produce the methanol as a product.

This invention relates to a supported catalyst system comprising: (i) at least one first catalyst component comprising a group 4 bis(phenolate) complex; (ii) at least one second catalyst component comprising a 2,6-bis(imino)pyridyl iron complex; (iii) activator; and (iv) support. The catalyst system may be used for preparing polyolefins, such a bimodal polyethylene, typically in a gas phase polymerization.

A composition, method, and article of manufacture are disclosed. The composition is a microcapsule that includes a transparent shell encapsulating a mixture comprising light upconversion molecules. The method is a method of forming a microcapsule, which includes obtaining light upconversion molecules, forming an emulsion of the light upconversion molecules and a shell formation solution, and encapsulating the light upconversion molecules in a transparent shell. The article of manufacture comprises the microcapsule.

A composition, method, and article of manufacture are disclosed. The composition includes a silica particle with light upconversion molecules bound to its surface. The method includes obtaining silica particles and light upconversion molecules having sidechains with reactive functional groups. The method further includes binding the light upconversion molecules to surfaces of the silica particles. The article of manufacture includes the composition.

Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO.sub.2.sup.− to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.