Diphosphites having an open and a closed 2,4-methylated outer unit and use thereof in hydroformylation.

Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

A high-activity double-metal-cyanide catalyst, a method for fabricating the same, and applications of the same are disclosed. An organic complexing ligand, which is formed via mixing fatty alcohols and alicyclic carbonates, is used to generate a high-activity double-metal-cyanide catalyst. The high-activity double-metal-cyanide catalyst includes at least one double-metal-cyanide compound, at least one organic complexing ligand, and an optional functionalized compound. The double-metal-cyanide catalyst of the present invention has a higher activity than the conventional double-metal-cyanide catalysts. The polyols generated by the present invention has an insignificant amount of high-molecular-weight compounds.

The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.

A compound capable of coordinating with a metal includes a chemical structure as shown in claim 1, in which: EPD represents a group having an electron pair donor atom; B and B′ are each independently an aryl group, a heteroaryl group, an alkenyl group, or alkynyl group, or B and B′ form a spirocyclic group; and R.sub.1, R.sub.2, and R.sub.3 are selected from various substituents.

Provided are a tricyclodecane dimethanol composition, in which a ratio of structural isomers is controlled, and a preparation method thereof.

A catalyst and a method for synthesizing cyclic carbonate using the catalyst are provided. The catalyst includes a metal complex shown in formula (I): ##STR00001##
wherein R.sup.1, R.sup.2, R.sup.4, and R.sup.5 are independently a C1-C25 alkyl group, a C1-C25 alkoxy group, a C3-C8 cycloalkyl group, a C6-C25 aryl group, a C6-C25 aryloxy group, a C7-C25 aralkyl group, a C7-C25 aralkoxy group, or halogen; R.sup.3 is hydrogen, a C1-C25 alkyl group, a C3-C8 cycloalkyl group, a C6-C25 aryl group, a C6-C25 aryloxy group, a C7-C25 aralkyl group, or a C7-C25 aralkoxy group; M is Sn or Ti; X is Cl, Br, I, or OAc; and L represents ether or furan.

The present disclosure relates to a method of using homogenous rhodium-BIPHEPHOS catalysts comprising for the hydroformylation of an allyl alcohol. In some aspects, the methods provided herein relate to the hydroformylation of allyl alcohol to produce 4-hydroxybutyraldehyde in a continuous process.

A method for making organo-metal material involves providing a metal ion source in a medium that removes metal ions from the source and forms 1D metal-containing coordination polymers that self-assemble and precipitate as at least one of a 2D and 3D coordination polymer material that can be thermally treated to produce a porous metal oxide material.

A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO.sub.2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.