Aspects of the present invention provide a modular reactor device having an outer housing, and a plurality of components contained within the outer housing, the components including: a reaction chamber; a fluid pathway connected to the reaction chamber; and a valve arranged to control flow of fluid within the device, wherein the outer housing has a plurality of connection ports providing connections from the exterior of the device to the interior, the connection ports including: a fluid input and a fluid output; an electrical input; and a pneumatic input; wherein either the electrical input or the pneumatic input is connected to the valve to provide for control of the valve, and either the fluid input or the fluid output is connected to the reaction chamber or the fluid pathway. Other aspects provide a base station for receiving and controlling a modular reactor device and methods for manufacturing the modular reactor device and for performing reactions using a modular reactor device.

The invention relates to a container holder 10, comprising a main body 12 which in turn comprises a gas inlet 16; a solution liquid outlet 18; a gas control valve 20 through which a gas enters the container 100 from the gas inlet; and a sealing means 22 for the container, which sealing means includes a passageway 24 for the input of gas and output of a solution in the container via an egress tube 19; wherein when the container is connected to the container holder through the sealing means, the gas control valve opens automatically, and when the container is disconnected the gas control valve is closed automatically. The invention further relates to a container panel 50 which includes two or more container holders. Also disclosed are methods of using these containers and container panels for synthesizing a polypeptide.

A reactor system for conducting multiple continuous reactions in parallel may include a preheating unit that includes an outer preheater shell and a plurality of heating tubes disposed within the preheating shell and arranged in parallel. The reactor system may include a reactor unit downstream of the preheating unit, the reactor unit comprising a plurality of reactor tubes disposed within a reactor shell and an outer heating element disposed about the reactor shell. An inlet end of at least one of the reactor tubes may be fluidly coupled to at least one of the heating tubes of the preheating unit. The reactor unit may include a multi-chamber separator downstream of the reactor unit, the multi-chamber separator having a plurality of separation chambers. At least one of the separation chambers may be fluidly coupled to at least one of the reactor tubes.

The invention consists of an assembly of a light (e.g., UV, visible, IR) source, a reaction vial holder and a photochemistry device that allows for conducting arrays of photochemical reaction conditions at room temperature with magnetic stirring. The photochemistry assembly is compatible with multiple reaction vial size holder.

Disclosed are modular chemical reaction systems and methods of using such chemical reaction systems. The disclosed systems can have a substrate layer and a plurality of modules selectively mounted to an outer surface of the substrate layer. The substrate layer can include flow connectors that cooperate with the modules to form a fluid flow pathway for performing at least one step of a chemical reaction. At least one of the modules can be a process module, such as a reactor or separator. The modules can also include at least one regulator module. The system can also include at least one analysis device that analyzes at least one characteristic of the chemical reaction as the reaction occurs. The system can also include processing circuitry that monitors and/or optimizes the chemical reaction based on feedback received from the analysis device or other system components.

Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a microwell array, which can comprise a formed, elastomeric grid of indentations or wells. Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a raft. Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.

The invention consists of an assembly of a light (e.g., UV, visible, IR) source, a reaction vial holder and a photochemistry device that allows for conducting arrays of photochemical reaction conditions at room temperature with magnetic stirring. The photochemistry assembly is compatible with multiple reaction vial size holder.

Embodiments of the disclosed subject matter provide an automated method and system to isolate and collect cells using computerized analysis of images of cells and their surroundings obtained from a digital imaging device or system. Embodiments of the disclosed subject matter make use of a microwell array, which can comprise a formed, elastomeric grid of indentations or wells. Many, most, or all of the wells in a microwell array can contain a releasable, microfabricated element, which can be referred to as a raft. Embodiments of the disclosed subject matter provide a system and method for cell collection that includes computerized identification and collection of rafts with isolated single cells or a specific group or groups of cells, eliminating the need for continuous human identification and selection.

Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.