A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.

A microreactor system that can mix fluids at precise timing has two inlets into which fluids are introduced and merges, in a channel, a first fluid introduced from a first inlet and a second fluid introduced from a second inlet, a first pump that sends the first fluid toward the inlets, and a second pump that sends the second fluid toward the inlets, a first fluid detector that detects an arrival of the first fluid at the first inlet, and a second fluid detector that detects an arrival of the second fluid at the second inlet.

A reactor includes: a heat exchange section including: a first flow channel configured to flow a reaction fluid and a second flow channel configured to flow a heat medium; an introduction path for a temperature sensor, extending from an insertion opening provided on a side surface of the heat exchange section to the first flow channel or the second flow channel; a pipe for a temperature sensor, connected to a side surface of the heat exchange section and communicating with the introduction path through the insertion opening; and a jig provided in the pipe. The jig is provided with a guide hole extending from the base end toward the tip end and opened toward the insertion opening of the introduction path. The guide hole is provided with a tapered hole directed from the base end toward the tip end.

The invention relates to a use of a fluorination gas, the elemental fluorine (F2) is preferably present in a high concentration, e.g. in a concentration of elemental fluorine (F2), especially of equal to much higher than 15% or even 20% by volume (i.e., at least 15% or even 20% by volume), and to a process for the manufacture of a fluorinated benzene starting from benzoic acid by direct fluorination employing a fluorination gas. The elemental fluorine (F.sub.2) is preferably present in high concentration, and subsequent decarboxylation of the benzoic acid hypofluorite obtained by direct fluorination. The process of the invention is also directed to the manufacture of benzoic acid hypofluorite by direct fluorination of benzoic acid. Especially the invention is of interest in the preparation of fluorinatedbenzene, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications.

A reactor system includes at least one reactant provided to perform a reaction. The system includes one or more sensors configured to detect sensor data regarding the reaction. The system includes processing circuitry configured to receive the sensor data from the one or more sensors, apply one or more machine learning models to the sensor data to generate a measurement regarding at least one of the reaction or an activity of at least one catalyst used to perform the reaction, and control at least one of a temperature of the reactor, a flow rate of the at least one reactant, or a concentration of the at least one reactant responsive to the measurement.

It discloses a polyether polyols for preparing flexible polyurethane foam, and a preparation method and application thereof. The method comprises the following steps: (1) carrying out a reaction on phosphorus oxychloride, epichlorohydrin, a first acidic catalyst and an inert solvent in a first microchannel reactor to obtain a chloroalkoxy phosphorus compound; (2) carrying out a reaction on the chloroalkoxy phosphorus compound, glycidol, a second acidic catalyst and an inert solvent in a second microchannel reactor to obtain a hydroxy compound; (3) carrying out a ring-opening reaction on the hydroxy compound, epoxy vegetable oil, a basic catalyst and an inert solvent in a third microchannel reactor to obtain a vegetable oil polyol; and (4) carrying out an addition polymerization reaction on the vegetable oil polyol, propylene oxide and an inert solvent in a fourth microchannel reactor to obtain the polyether polyols for preparing flexible polyurethane foam.

The method of the polyurethane polyol comprises (1) dissolving 2,3-epoxybutane and an acid catalyst in an inert solvent to obtain a solution A; dissolving triethylene glycol in an inert solvent to obtain a solution B; and dissolving epoxy vegetable oil in an inert solvent to obtain a solution C; (2) respectively and simultaneously pumping the solutions A and B into a first micromixer for mixing; (3) pumping the solution C and an effluent of the first microreactor into a second micromixer for mixing while carrying out step (2); and (4) dissolving the vegetable oil polyol in an inert solvent to obtain a solution D; dissolving epoxypropane and an alkaline catalyst in an inert solvent to obtain a solution E; and pumping the solution D and the solution E into a tank reactor for reaction, thereby obtaining the polyurethane polyol.

Disclosed are methods and conditions for manufacturing a polyethylene polymer or copolymer in a liquid/liquid biphasic non-adiabatic reaction, and the compositions and articles made therefrom.

A method for determining polymer concentration can include synthesizing a polymer in a reactor under a set of parameters, wherein the reactor comprises a solution mixture having a refractive index, and wherein the solution mixture comprises a solvent, a polymer, and optionally a monomer, wherein the solution mixture has a polymer concentration; measuring the refractive index of the solution mixture; comparing the refractive index of the solution mixture with a calibration curve; and identifying the polymer concentration in the solution mixture. A system for determining polymer concentration can include a reactor containing a solution mixture comprising a solvent, a polymer, and optionally a monomer; a flash vessel fluidly coupled to the reactor to receive the solution mixture from the reactor; and a first refractometer fluidly coupled to the reactor, placed between the reactor and the flash vessel, and configured to measure a refractive index of the solution mixture.

The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, CC coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.