A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

This invention relates to a process and an apparatus for conducting simultaneous endothermic and exothermic reactions in a microchannel reactor. A start-up procedure for the microchannel reactor is disclosed.

The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.

Disclosed is a reactor system that contains multiple millireactors, each including a millitube, a first feed line, a second feed line, and a third feed line. Each of the first and second feed lines has a hydraulic damper disposed therein. Also disclosed is a process for conducting in a millitube a triphasic flow reaction that requires a liquid reactant, a gas reactant, and a catalyst.

A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.

A fluid processing assembly includes a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.

Fluidic systems, modules, and associated methods are generally described. In some embodiments, a fluidic system comprises a module which is configured such that fluid may flow therethrough with a relatively uniform time-averaged linear flow rate (i.e., the time-averaged flow rate that is perpendicular to the transverse cross-sectional area) and/or time-averaged flux across the transverse cross-sectional area of the module. Advantageously, such modules may behave in a way such that the time-averaged linear flow rate and/or time-averaged flux exhibits minimal or no dependence on the transverse cross-sectional area thereof. This may allow for modules to be scaled-up in a relatively facile manner by merely increasing the transverse cross-sectional area, which may eliminate or substantially reduce the need for other components of the module to be redesigned upon scale-up. In some embodiments, modules may be scaled-up in a manner that requires no or minimal chemical process adjustments.

A continuous-flow preparation method for an amino alcohol compound using a micro-reaction system. The micro-reaction system includes a feed pump, a micromixer, a microchannel reactor, and a back pressure valve. An aldehyde compound and an amine compound are simultaneously fed to the micro-mixer for mixing to obtain a mixed solution. The mixed solution is directly fed to the micro-channel reactor and undergoes an addition reaction. The reaction mixture is collected, and subjected to concentration, separation and purification to obtain the desired amino alcohol compound.

A microfluidics-based nanoparticle synthesis system, a device and a synthesis method thereof are provided. The nanoparticle synthesis system comprises: a microfluidic chip; a reagent bottle which is connected with the microfluidic chip; and a flow control assembly comprising a pressure controller which is used for controlling the pressure in the reagent bottle. The system achieves high-accuracy flow control, and a microfluidic chip that can achieve high-efficiency and rapid mixing is also used in combination to finally achieve high-throughput and high-uniformity nanoparticle synthesis. A user may adjust the same instrument as required to achieve different throughputs without redesigning the instrument.