The purpose of the present invention is to provide a new disintegrative particulate composition having an optimal balance between the tablet hardness and disintegrability that are mutually opposing properties, and disintegrating tablets for pharmaceuticals and various kinds of foods comprising said composition.

The present invention relates to a disintegrative particulate composition comprising milled lactose and/or granulated lactose as an excipient, and to a disintegrating tablet for pharmaceuticals or foods, comprising the disintegrative particulate composition, especially the tablet having tablet hardness of from 20 to 200 N, and disintegration time in water of from 1 to 60 sec.

A food forming and shaping device. The food forming and shaping device may comprise: a mixer, forming and shaping portion, and cutter. The mixer may comprise: at binder container, a cereal base container, and a hopper. The binder container may store and dispense a binder to the hopper. The cereal base container may store and dispense a cereal base to the hopper. The hopper may mix the cereal base and the binder to create the food mixture. The hopper may pour the food mixture onto a mixing surface of the frame. The forming and shaping portion may comprise: a frame; rollers, motors, pistons, and top mixing surface. The rollers may be rotatably connected to the frame and may be adjacent to one another. The motors may actuate the rollers, such that the motors may actuate the feed roll heads in the same direction. When the food mixture is placed onto the top mixing surface, the shoulder plate may move the food mixture to the rollers. The rollers may roll and press the food mixture to create a formed and shaped food mixture. The pistons may be connected to the frame and may shift one or more rollers to create various densities for the food mixture. The conveyor belt may move the formed and shaped food mixture to the cutter of the food forming and shaping device. The cutter may comprise one or more cutting instruments for slicing the formed and shaped food mixture to create one or more food bar portions.

A food forming and shaping device. The food forming and shaping device may comprise: a mixer, forming and shaping portion, and cutter. The mixer may comprise: at binder container, a cereal base container, and a hopper. The binder container may store and dispense a binder to the hopper. The cereal base container may store and dispense a cereal base to the hopper. The hopper may mix the cereal base and the binder to create the food mixture. The hopper may pour the food mixture onto a mixing surface of the frame. The forming and shaping portion may comprise: a frame; rollers, motors, pistons, and top mixing surface. The rollers may be rotatably connected to the frame and may be adjacent to one another. The motors may actuate the rollers, such that the motors may actuate the feed roll heads in the same direction. When the food mixture is placed onto the top mixing surface, the shoulder plate may move the food mixture to the rollers. The rollers may roll and press the food mixture to create a formed and shaped food mixture. The pistons may be connected to the frame and may shift one or more rollers to create various densities for the food mixture. The conveyor belt may move the formed and shaped food mixture to the cutter of the food forming and shaping device. The cutter may comprise one or more cutting instruments for slicing the formed and shaped food mixture to create one or more food bar portions.

The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

An edible energy tablet containing at least 80 weight % carbohydrates for consumption during exercise, is fabricated by a process including providing tablet material free of hydrophobic and/or PEG lubricants and free of CO.sub.2 sources. The tablet material includes a sucrose and dextrose mixture of 77-95 wt. %, maltodextrin of 2-13 wt. %, an edible soluble oil of 0.2-2.0 wt. %, and an edible acid of 1-4 wt. %. The tablet material is introduced to a tablet press that alternately moves first and second punches towards and away from one another to compress the tablet material to form and release a tablet. A punch cleaner engaged with the first and second punches removes tablet material from the punches after tablet release. The tablet has a diameter of 1.2 to 3.8 cm, a thickness of 0.6 cm to 2.3 cm, and a resistance to breakage forces of 8.5 to 30 kilopounds.

An edible energy tablet containing at least 80 weight % carbohydrates for consumption during exercise, is fabricated by a process including providing tablet material free of hydrophobic and/or PEG lubricants and free of CO.sub.2 sources. The tablet material includes a sucrose and dextrose mixture of 77-95 wt. %, maltodextrin of 2-13 wt. %, an edible soluble oil of 0.2-2.0 wt. %, and an edible acid of 1-4 wt. %. The tablet material is introduced to a tablet press that alternately moves first and second punches towards and away from one another to compress the tablet material to form and release a tablet. A punch cleaner engaged with the first and second punches removes tablet material from the punches after tablet release. The tablet has a diameter of 1.2 to 3.8 cm, a thickness of 0.6 cm to 2.3 cm, and a resistance to breakage forces of 8.5 to 30 kilopounds.

A composition may include an alkaline earth metal salt. The alkaline earth metal salt may have an angle of repose less than or equal to about 34. The alkaline earth salt may be used to form a tablet. The tablet may have a friability less than or equal to about 1%. A method of forming an alkaline earth metal salt may include providing a slurry that includes an alkaline earth metal and an organic polyatomic anion, and spray drying the slurry to form a spray dried alkaline earth metal salt. The slurry temperature may be greater than or equal to about 50° C. A method of forming a tablet may include tableting a non-agglomerated alkaline earth metal salt.

A composition may include an alkaline earth metal salt. The alkaline earth metal salt may have an angle of repose less than or equal to about 34. The alkaline earth salt may be used to form a tablet. The tablet may have a friability less than or equal to about 1%. A method of forming an alkaline earth metal salt may include providing a slurry that includes an alkaline earth metal and an organic polyatomic anion, and spray drying the slurry to form a spray dried alkaline earth metal salt. The slurry temperature may be greater than or equal to about 50° C. A method of forming a tablet may include tableting a non-agglomerated alkaline earth metal salt.

A method of producing coffee tablets for making coffee from roasted coffee beans and other ingredients, including: roasting and grinding coffee beans to obtain two or three fractions of different granularity, forming a serving dose and feeding ingredients sequentially into a moistened press matrix and mixing them, pressing tablets and simultaneously heating a superficial layer, controlling and packaging tablets. A blend, a roasting degree, a fraction size, weight and density are selected in a coffee tablet in such a manner so that a cup of premium coffee could be brewed at home, in an office, in a car, a train and a plane.