Separate cleaning assembly for magnet assemblies formed by at least one magnet rod, wiper assembly and magnet handle device, the cleaning assembly including a base and vertically extending main body, wherein the cleaning assembly includes retaining means for retaining the magnet assembly to the main body and receiving means for receiving and accommodating the wiper assembly, wherein the receiving means for the wiper assembly is arranged to moving means arranged for moving the wiper assembly in longitudinal direction of the magnet rods.

Systems and methods for handling a variety of sample and preparatory fluids in a rack specifically configured for compatibility with predetermined liquid handlers such as automated pipettors or multi-channel manual pipettors and set up for magnetic based sample preparation. The rack can hold all of the necessary sample and reagent vials, and present them to the pipettor in some embodiments in a way that allows for parallel operation. The rack includes slidable magnets that in some embodiments are actuatable directly by the pipettor, eliminating a layer of complexity. Combined with a suitable pipettor the magnet enabled rack supports a multistep magnetic based sample preparation capability in a high throughput manner at one station that enhances sample purity throughout magnetic separation processes.

Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower portion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.

A system is provided for the quantitative magnetic separation of magnetic objects (e.g., particles or cells). The system uses magnetic ratcheting over arrays of ferromagnetic elements having gradient spacing manifested in various pitch zones that are encountered by the magnetic objects as they traverse the array. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based, for example, on surface expression of proteins or molecules that are bound to magnetic particles. The system includes a substrate or chip having the array of ferromagnetic elements with increasing lateral pitch and an externally driven magnet device that generates a cycling magnetic field. Magnetic objects with higher IOC separate and equilibrate along the array at larger pitches. The system can be used for the differential sorting of particles and cells of interest.

Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.

The present invention is directed to a method for sorting biological objects including the steps of providing a magnetic device that includes a conduit or channel having upstream and downstream sections and a magnetic means for generating first and second magnetic fields in the upstream and downstream sections, respectively; flowing a sample fluid that includes magnetically labeled biological objects and unlabeled biological objects through the upstream section to magnetically saturate the magnetically labeled biological objects by the first magnetic field; and flowing the sample fluid from the upstream section continuously to the downstream section to collect the magnetically labeled biological objects on a wall of the downstream section by the second magnetic field, wherein the first magnetic field in the upstream section has a higher average field strength than the second magnetic field in the downstream section.

A planar magnet for magnetic density separation, comprising an array of pole pieces succeeding in longitudinal direction of a mounting plane, each pole piece having a body extending transversely along the mounting plane with a substantially constant cross section that includes a top segment that is curved to distribute the magnetic field associated with the top surface of the pole piece such that its strength transverse to the mounting plane is substantially uniformly distributed in planes parallel to the mounting plane, the curved top segments having a width (w) in longitudinal direction of the mounting plane and a maximum height (h) transverse to the mounting plane, wherein the top segments of successive pole pieces are unequal in height and/or width.

A magnetic separator comprising a concurrent tank body and a permanently magnetic barrel, wherein the rotation direction of the permanently magnetic barrel is opposite to the inlet direction of the ore slurry; a stationary magnetic system is provided; the inlet side of the tank body is connected to a tubular ore-feeding box; the included angle of the magnetic system is in the range of 200°-280°; the region of the magnetic system closer to the inlet side of the tank body is a refining region of the magnetic system; at an upstream position in the tank body, a plurality of rinsing water pipes are provided; several spraying nozzles are provided at intervals on the rinsing water pipes; and several stripe-shaped magnetically conductive thin sheets are provided at intervals on an inner wall of the permanently magnetic barrel.

A magnetic filter 10 includes first and second separation chambers 10, 12. The separation chambers 10, 12 each have an inlet and an outlet, and the separation chambers 10, 12 are joined together such that the inlets of the first and second chambers are adjacent, and the outlets of the first and second chambers are adjacent. An inlet port arrangement 28 connects both inlets to a single inlet pipe, and an outlet port arrangement 30 connects both outlets to a single outlet pipe.

The present invention relates to novel modules for transferring magnetic beads, an automated system comprising the same and a method for extracting nucleic acids using the same. The specifically designed magnet module and cover module of the present invention can be employed in the automated liquid handling apparatus by means of pre-existing moving modules (e.g., pipettor module) of the apparatus. The present invention enables a bead transfer-type method for extracting nucleic acids to be performed in an automated manner on the automated liquid handling apparatus. The present invention provides advantages of higher level of automation, more reduced cost and no need for another separate liquid handling apparatus compared to the conventional bead transfer-type method usually performed in the small apparatus designed to be used only for this bead transfer-type method. Also, the present method has the merits of more shortened reaction time compared to the conventional liquid transfer-type method.