The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A magnetic separator and methods of use are provided for continuous feeding of a material feed flow at high production feed rates without rotation of large heavy steel parts through high intensity magnetic fields. The magnetic separators use stationary magnetic matrices and redirect a material feed flow and a flushing fluid flow between the stationary magnetic matrices. Magnetic fields within the stationary magnetic matrices are modulated based on reception of a material feed flow or a flushing fluid flow to optimize separation processes and purging processes. The magnetic separators also collect and direct the separated components to isolated collection sites.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A detection device of a substance to be measured according to an embodiment of the present disclosure is intended to conveniently detect a bio-related substance such as a bacteria or a fungus. The detection device according to an embodiment of the present disclosure includes, a container that contains solution and a composite particle combining a substance to be measured and a magnetic labeling substance, a magnetic field applying unit that applies a magnetic field to a predetermined region so as to collect the composite particles, wherein spatial light is incident to the predetermined region other than lower region of the container, an imaging unit for imaging the composite particles collected in the predetermined region where the spatial light is incident, a detection unit that detects the composite particles based on the image captured by the imaging unit.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A device and method for extracting particles contained in a ferrofluid medium are provided. Such methods may comprise suspending particles of different sizes in a ferrofluid medium and containing the ferrofluid medium in a cylindrical reservoir, and applying a first magnetic field to at least a portion of the reservoir. The first magnetic field is configured to indirectly exert a force on at least a portion of the particles of a predetermined size, and direct the portion of particles in a desired direction.

Provided herein are devices and methods for sample isolation comprising a planar member configured to rotate around a bearing, and a plurality of apertures positioned at an angle to the planar member. Exemplary embodiments relate generally to the field of sample isolation, and more particularly to sample isolation using centrifugal and magnetic forces.

Embodiments of systems and methods for automated sample handling are disclosed. In an example, a system for automated sample handling includes reaction wells, a magnet, a magnetic manipulator, and a punch. The reaction wells are configured to each hold a reagent and collectively move horizontally. A first reaction well holds magnetic beads, and a second reaction well is partitioned by a seal. The magnet is configured to move vertically and capture the magnetic beads on a bottom surface of the first reaction well when moving to an upper position beneath the first reaction well. The magnetic manipulator is configured to manipulate the magnetic beads and includes a magnetic rod configured to move vertically to be above or in the first reaction well and a sheath below the magnetic rod and configured to move vertically and receive the magnetic rod. The punch is configured to move vertically and break the seal of the second reaction well when moving to a lower position in the second reaction well.

A biological component concentration fluid assembly includes magnetizing microparticles that are surface-activated to bind with (or are bound to) a biological component; a multi-fluid density gradient column with a first fluid layer, a second fluid layer, and a third fluid layer; and a magnet to attract and draw the magnetizing microparticles from the first fluid layer, through the second fluid layer, and into the third fluid layer. The first fluid layer has a first fluid density, and a second fluid layer has a second fluid density that is greater than the first fluid density, and is positioned beneath the first fluid layer. A third fluid layer has a third fluid density that is greater than the second fluid density and is positioned beneath the second fluid layer. The second and third fluid layers in this example are formulated to interact with the surface of the magnetizing microparticles.

There is provided a fluid treatment separator and a method of treating fluid such as tailings from tailings ponds resulting from oil sands production. A fluid treatment separator may be used for treatment of a mixture containing at least oil and water. The separator includes a mixing chamber, an inlet and at least one outlet. The mixing chamber defines a flow path between the inlet and the at least one outlet. The inlet includes a nozzle arranged to introduce turbulence to the mixture along the flow path. At least one magnet is arranged to apply a magnetic field to the mixture along the flow path.