The invention relates to a refillable device (1) for spraying an active substance, comprising a reservoir (2) containing at least one active substance, said device (1) being equipped with a piezoelectric spraying mechanism (6). The invention also relates to the use of said device for spraying an active substance in a controlled manner from a distance in a desired direction. Said device is attached to the subject to be treated and can be used multi-directionally independently of the movements of the subject.

In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

An aerosol-generating device is provided, including: a piezoelectric transducer; drive circuitry connected to the piezoelectric transducer and configured to apply an oscillating current to the transducer; and control circuitry connected to the drive circuitry and configured to monitor a resonant behavior of the piezoelectric transducer, the control circuitry being further configured to control the operation of the drive circuitry based on the resonant behavior of the piezoelectric transducer, in which the piezoelectric transducer forms part of a transducer assembly in a liquid pump, and the transducer assembly includes a membrane or surface configured to contact a liquid aerosol-forming substrate, the transducer assembly being configured to drive the membrane or surface into vibration, the vibration of the membrane or surface forcing the liquid through an adjacent liquid valve in the liquid pump. A method of operating an aerosol generating device is also provided.

An aerosol-generating device includes: a housing having a liquid storage cavity for accommodating an aerosol-generating substrate; a metal element arranged outside the liquid storage cavity; a static electricity generating assembly including a positive terminal and a negative terminal, one of the positive terminal and the negative terminal being electrically connected to the metal element so as to cause a part of the aerosol-generating substrate that is close to the metal element in the liquid storage cavity to be charged by electrostatic induction when the static electricity generating assembly is electrified; and a vaporization sheet, that, when electrified, vaporizes the charged aerosol-generating substrate to generate a charged aerosol.

The invention relates to methods for generating an aerosol by nebulization of a composition comprising polyclonal immunoglobulin (Ig). The selection of an efficient membrane nebulizer and a composition optimized for nebulization with such membrane nebulizer results in a particularly efficient method of generating an aerosol for administration of Ig to the respiratory tract.

This invention is a novel aroma candle light including a light body, a water spray formation channel, an ultrasonic device and a water tank; a water spray outlet is formed on a top part of the water spray formation channel; an LED light panel is fixedly mounted at the water spray outlet; the ultrasonic device includes an ultrasonic plate, an ultrasonic plate fixing member and a silicone rubber casing; the ultrasonic plate is disposed inside the silicone rubber casing; the ultrasonic plate fixing member has a top end which is provided with a recess; the silicone rubber casing is mounted inside the recess; the silicone rubber casing has a top part which is provided with a plurality of first guiding grooves; a plurality of second guiding grooves are formed inside the recess; the ultrasonic plate fixing member is disposed at an opening at a top part of the water tank.

An ice bucket with a spray and light-emitting function comprises: a transparent housing and a light-transmitting base supporting the housing, wherein the housing is separated from an ice storage chamber and a mist generating chamber by a partition plate, the ice storage chamber are in partial communication with the mist generating chamber via the partition plate and the mist generating chamber is in communication with the base through an air duct, and wherein the base is provided with a power source, a lamp, an atomizer, and a fan, the lamp, the atomizer, and the fan are electrically connected to a power source, the fan is configured to blow a mist generated by the atomizer out of the mist generating chamber through the air duct and guide the atomizer to the ice storage chamber, and a light generated by the lamp is irradiated to the housing through the base.

An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device for delivery of a substance into a body through respiration includes a liquid container; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes a plurality of nanoparticles in a nanoemulsion, the nanoparticles including the encapsulation of the substance to be delivered into the body through respiration. The nanoemulsion preferably is produced using a microfluidizing machine.

An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

A nebulizer has an aperture plate, a mounting, an actuator, and an aperture plate drive circuit (2-4). A controller measures an electrical drive parameter at each of a plurality of measuring points, each measuring point having a drive frequency; and based on the values of the parameter at the measuring points makes a determination of optimum drive frequency and also an end-of-dose prediction. The controller performs a short scan at regular sub-second intervals at which drive current is measured at two measuring points with different drive frequencies. According to drive parameter measurements at these points the controller determines if a full scan sweeping across a larger number of measuring points should be performed. The full scan provides the optimum drive frequency for the device and also an end of dose indication.