A method of verifying sterilization comprises performing a sterilization cycle on a sterilizing cabinet, opening the door with the first filter overlying the vent port by a single user being non-sterile and ungowned and examining the first filter, by the single user being non-sterile and ungowned, to verify the integrity of the sterilization cycle in the sterilizing device, determining if the integrity of the first filter is acceptable by the single user being non-sterile and ungowned, and removing, by the single user being sterile and gowned, through the access port at least one tray from the interior of the sterilizing cabinet if the integrity of the first filter is acceptable.

A closure system for a screw top container intended to contain a pharmaceutical or surgical medium comprises: a screw cap including a main body comprised of an annular wall with an internal thread for cooperating with an external thread adjacent an open end of the container, the body having a first open end for receiving the open end of the container and a second end closed by an end disc; a sealing formation within the main body for forming a seal with the open end of the container; and a tamper-evident band connected to the screw cap at the open end of the main body by at least one severable linkage, wherein the screw cap, sealing formation and tamper-evident band are integrally formed as a single unit for maintaining a hermetic seal with the container throughout a terminal sterilisation process.

Cleaning and disinfection of multi-use plastic materials used in the food industry can be accomplished by using microwave radiation in combination with an electrolyte solution, thereby achieving at least 99.99% killing of microorganisms present on and inside the plastic device. Cleaning and disinfection of plastic trays used in security check screening can also be accomplished using microwave radiation in combination with an aqueous solution, thereby achieving at least 99.9% killing of pathogenic microorganisms present on the plastic tray.

Staple cartridges including bioabsorbable staples are disclosed. The staples are configured such that they are bioabsorbable within a desired time frame.

A heating system for containers for pharmaceutical use includes a heating tunnel; an entry station to the heating tunnel; an exit station from the heating tunnel and a transport device for containers for pharmaceutical use having at least one transport branch defining a first transport path between the entry station and the exit station from the heating tunnel and at least one return branch defining a second transport path between the exit station and the entry station. The transport branch and the return branch of the transport device may pass through the heating tunnel.

A drug delivery device that includes a body storing a VEGF antagonist, a plunger rod contacting a stopper inside the body, and a flange coupled to the body. The body is silicone-free. The plunger rod includes protrusions and the flange includes a proximal collar and slots positioned along the proximal collar. The flange is configured such that when the protrusions and slots are misaligned, distal movement of the plunger rod relative to the body is limited upon the protrusions contacting the proximal collar to prime the drug delivery device. The flange is configured such that when the protrusions and slots are aligned, distal movement of the plunger rod relative to the body is limited upon the protrusions extending into the slots to deliver the VEGF antagonist.

Disclosed is a system for preventing scaling and deposit formation in a sterile air heat exchanger of a system for aseptic packaging within laminated carton packages, and a process for eliminating hydrogen peroxide residues in aseptic laminated carton packaging systems, characterized in that it comprises providing a supply of water for scrubbing sterile air that has the following properties: (a) maximum conductivity at 20 C. of 2.0 micromhos; and (b) a maximum silica content of 0.1 ppm.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes one or more conjugated glycosaminoglycans having a polymer backbone having a reactive functional moiety conjugated to an amine group having one or more moieties that inhibit and/or prevent one or more of oxidation and hydrolytic degradation of the polymer backbone during use in the eye; wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

A medical device with audio output for use in a sterile field may include a housing and an audio output device. The housing may include an interior surface and an exterior surface, the interior surface may define an interior space of the housing including the audio output device, and the interior space of the housing may be fluidically sealed from an external environment by the housing. The audio output device may include a speaker and/or an audio exciter.

A sterilization system for sterilizing an article may include a hydroxyl generation system configured to generate a first flow of hydroxyl ions and a gas transport system configured to transport the first flow of hydroxyl ions to the article and expose the article to the first flow of hydroxyl ions to sterilize the article.