The present disclosure relates to the field of biomedical technology, and specifically to an antibody against human immunodeficiency virus type 1 p24 and type 2 p26 and uses thereof. The present disclosure provides an antibody or antigen-binding fragment thereof capable of specifically binding to human immunodeficiency virus type 1 p24 protein and human immunodeficiency virus type 2 p26 protein. The present disclosure also provides an antibody pair, kit and related uses thereof. Utilizing the antibody pair in immunoassays enables the simultaneous detection of HIV-1 p24 and HIV-2 p26 antigens, with the advantage of a lower limit of detection (LOD).

The disclosure provides methods for promoting affinity maturation, and in particular in vivo affinity maturation, of antibodies. The disclosure also provides a system of affinity maturation of an antibody as well as compositions comprising antibodies generated from methods described herein and polynucleotides encoding such systems.

The disclosure provides methods for promoting affinity maturation, and in particular in vivo affinity maturation, of antibodies. The disclosure also provides a system of affinity maturation of an antibody as well as compositions comprising antibodies generated from methods described herein and polynucleotides encoding such systems.

The present invention relates to methods and compositions for engineering B cells to express transgenic B cell receptor (BCR) for antigen-induced antibody secretion, compositions, methods and uses thereof in immunotherapy.

The present invention relates to a cytotoxic agent for the prophylaxis and/or treatment of a viral infection which is configured for the selective binding to a membrane receptor of virus-infected T lymphocytes, a pharmaceutical composition containing said cytotoxic agent, the use of the cytotoxic agent for the prophylaxis and/or treatment of viral infections, a method of finding cytotoxic agents, the use of a membrane receptor of virus-infected T lymphocytes which is overexpressed in comparison to non-infected T lymphocytes for the diagnosis of a viral infection.