Patent classifications
C07K16/1145
Human broadly neutralizing antibodies against the membrane-proximal external region of HIV Env for vaccine design and intervention
The present disclosure relates to anti-HIV antibodies and their use in the treatment or prevention of HIV/AIDS and in the development of HIV vaccines.
Compositions and methods for membrane protein structure determination
Disclosed herein are compositions and methods for determining the structure of a membrane protein. An epitope from a membrane-proximal external region (MPER) from a viral envelope protein can be grafted on to a variety of diverse membrane proteins to allow for binding structurally characterized antibody fragments, which can aid structural studies. ##STR00001##
COMPOSITIONS AND METHODS FOR HIV LATENCY REVERSAL
In some embodiments, the subject matter described herein relates to a bispecific molecule for the treatment of HIV-1 latent infections, the molecule comprising an anti-CD4 iMab portion and an IL-15/IL-15R Fc portion.
CHIMERIC ANTIBODIES AND METHODS OF MAKING AND USING SAME
The present disclosure provides antigen binding regions and chimeric antibodies, as well as methods of making and using the same.