The invention relates to a process for extruding plastic compositions. The process in particular relates to the conveying, kneading and/or mixing of plastic compositions, in particular of polymer melts and mixtures of polymer melts, above all thermoplastics and elastomers, particularly preferably polycarbonate and polycarbonate blends, also with the incorporation of other substances such as for example solids, liquids, gases or other polymers or other polymer blends.

A screw includes a screw main body, a conveyance portion conveying a raw material, and a passage provided in the screw main body. The passage includes a first passage element, a second passage element, and a third passage element. The screw main body has a plurality of cylindrical bodies arranged in an axial direction of the rotating shaft. At least a portion of the conveyance portion is formed on outer peripheral surfaces of the cylindrical bodies adjacent to each other, and the passage is formed in the cylindrical body so as to cross over between the adjacent cylindrical bodies.

Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.

Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.

An extended-release bio absorbable subcutaneous medicinal dosage delivery implant system includes an implant fabricated from a highly homogeneously mixed composition including a medicinal agent in combination with release controlling polymers which include poly (DL-lactide) and polycaprolactone. In one implementation for treating an opioid disease, the formulation composition includes naltrexone at 40 weight percent, poly (DL-lactide) in the range between 36 and 46.4 weight percent, and polycaprolactone in the range between 24 and 11.6 weight percent. In addition, in order to provide anti-biofouling quality and prevent foreign body adsorption/interaction with the material of the implant, polyethylene glycol is added in a preferred content of 2.0%. The manufacturing process includes hot melt extrusion and a mini jet based implant formation stage with the optimized process space were the temperature of the process ranges from 170° C.-180° C., mixing time through the HME process ranging from 8 minutes to 12 minutes, and injection time ranging from 8 seconds to 12 seconds. The resulting implants have a uniquely shaped free of defects bio absorbable solid body.

A screw element which has an axially asymmetrical screw cross-sectional profile which has at least two construction points located within the screw cross-sectional profile is provided. The screw element is suitable for use in an extruder having two drive shafts which rotate in the same direction and at the same speed, in order to process or produce plastic masses as an extrudate. Also, an arrangement of two identical or different screw elements in an extruder having two drive shafts which rotate in the same direction and at the same speed is provided. An extruder which is equipped with two identical or different screw elements and has two drive shafts which rotate in the same direction and at the same speed is provided. Furthermore, the use of the screw element according to the invention for processing or producing plastic masses is provided.

An extruder configured to extrude a solid raw material containing moisture includes a barrel, a hopper, a discharge port, and a slot portion, through which the inside and outside of the barrel communicate each other, is provided between the discharge port and the hopper; a screw, and a heater mounted on the barrel to heat the raw material. Raw material introduced into the barrel through the hopper is heated by the heater while being transferred within the barrel through the screw. A kneading zone, in which raw materials transferred by the screw threads are compressed, is formed on the screw. Since the raw material is melted within the barrel, a heating temperature of the heater and an axial rotation speed of the screw are controlled so that a sealing membrane that shields an inner transverse section of the barrel is formed from the liquid raw material in the kneading zone.

A dispersive mixing element for co-rotating twin screw extruder is disclosed. The element for co-rotating twin screw extruder comprises of a continuous flight helically formed thereon having a lead ‘L’, wherein either the flight transforms at least once from an integer lobe flight into a non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to an integer lobe flight in a fraction of the lead ‘L’ or the flight transforms at least once from a non-integer lobe flight into an integer lobe flight in a fraction of the lead ‘L’ and transforms back to a non-integer lobe flight in a fraction of the lead ‘L’.

A dispersive mixing element for co-rotating twin screw extruder is disclosed. The element for co-rotating twin screw extruder comprises of a continuous flight helically formed thereon having a lead ‘L’, wherein either the flight transforms at least once from an integer lobe flight into a non-integer lobe flight in a fraction of the lead ‘L’ and transforms back to an integer lobe flight in a fraction of the lead ‘L’ or the flight transforms at least once from a non-integer lobe flight into an integer lobe flight in a fraction of the lead ‘L’ and transforms back to a non-integer lobe flight in a fraction of the lead ‘L’.

A composite and method for producing the composite by incorporating wood or wood pulp fibres with a suitable thermoplastic polymer and coupling agent are described. Homogeneous, void-free transparent/translucent thermoplastic materials in the form of pellets, films or three-dimensional moldable products are produced. The wood pulp fibres can be discrete natural fibres, and flexible assemblies of nano to micro elements, e.g., assemblies of aggregated carbon nanotubes. It is also possible to use our vacuum-assisted co-extrusion process to produce hybrid composites comprising the wood pulp fibre and a further rigid fibre, like glass or carbon fibres, and a flexible fibre or fibrillar network, like cellulose fibres or cellulose filaments. The thermoplastic resin can be, but not limited to, polyolefins, like polypropylene or polyethylene, or polyesters, like polylactic acid, or co-polymers, like acrylonitrile-butadiene-styrene terpolymer.