A genetically modified cat produced through gene editing with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the genetically modified cat by targeting either the gene sequence of the Fel d I locus or sequences flanking the coding sequence of the two contiguous Fel d I genes with specialized gene editing constructs. The genotype and phenotype of the genetically modified cat is transmissible to its offspring.

Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.

A system comprising data input ports and sensors operatively in communication with the data input ports; a data processor operatively in communication with the sensors; and software aggregates data in the data processor obtained from the plurality of sensors into a set of incoming data streams; time stamps, organizes, and records the organized time stamped set of incoming data streams in the data recorder; and performs a predetermined set of algorithmic manipulations on the organized time stamped set of incoming data streams to allow display of the organized time stamped set of incoming data streams in an actionable format in real time on the display to make a human aware of events occurring in a monitored area and provide an actionable insight.