Provided herein are materials, methods, and devices for the targeted delivery of agents. In particular, provided herein are materials, methods, and devices for the targeted delivery of agents to the atria or ventricles of the heart.

An automatic feeding system for preparing at least one feed ration from a plurality of feed types includes a feed kitchen with multiple feed storage places for storing a plurality of feed types, a feed distributing device for receiving feed from the feed kitchen, a feed loading device to load feed from each of the feed storage places into the feed distributing device, and a control system to control the automatic feeding system. The control system includes a graphical user interface with a display screen, including a floor plan with first representations of each of the feed storage places, which representations are formed based on at least the feed storage location data, and second representations of the feed types.

Genetically modified rodents such as mice and rats, and methods and compositions for making and using the same, are provided. The rodents comprise a humanization of at least one endogenous rodent Tmprss gene, such as an endogenous rodent Tmprss2, Tmprss4, or Tmprss11d gene.

In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.

This invention relates to polynucleotides encoding mini-dystrophin proteins, viral vectors comprising the same, and methods of using the same for delivery of mini-dystrophin to a cell or a subject.

A method is provided for establishing an ulcerative colitis (UC) animal model and use of the model. The ulcerative colitis animal model uses Canis lupus familiaris dogs as the modeling animals and uses acetic acid to induce canine ulcerative colitis. The experimental results can be directly generalized to the human body. The modeling manner is easy to operate, establishes a stable model, is easy to reproduce, and has a low cost, which provides more animal model options for evaluation of responsiveness to drugs and therapeutic effect in research and development of UC therapeutic drugs.

An ergonomic training harness for use with an animal, the harness having a back panel with an outward-facing surface and an inward-facing surface and a chest panel with an outward-facing surface and an inward-facing surface. The harness also includes a chest strap having a first end and a second end, wherein each of the first end and the second end are coupled to the back panel. Additionally, the harness includes an underbelly strap coupled to the back panel, and a longitudinal strap coupled to the chest panel, the longitudinal strap having a first loop portion and a second loop portion. The chest strap is configured to pass through the first loop portion of the longitudinal strap and the underbelly strap is configured to pass through the second loop portion of the longitudinal strap.

A system comprising data input ports and sensors operatively in communication with the data input ports; a data processor operatively in communication with the sensors; and software aggregates data in the data processor obtained from the plurality of sensors into a set of incoming data streams; time stamps, organizes, and records the organized time stamped set of incoming data streams in the data recorder; and performs a predetermined set of algorithmic manipulations on the organized time stamped set of incoming data streams to allow display of the organized time stamped set of incoming data streams in an actionable format in real time on the display to make a human aware of events occurring in a monitored area and provide an actionable insight.

The subject invention provides materials and methods for producing animals with short hair length. In a preferred embodiment, this is accomplished by altering in the animal the nucleotide sequence that encodes the prolactin receptor (PRLR) protein such that a truncated version of the protein is produced. Advantageously, and surprisingly, the truncated protein produced according to the subject invention retains lactogenic functionality, but causes the animal to have a short-hair coat.

A hoof protection apparatus and method includes a hoof support platform with a top, a bottom, a front, a first side, a second side, and a space between the first side and the second side, where the front is connected by a hinge device to the first side and by a hinge device to the second side such that the first side is independently movable and such that the second side is independently movable. At least three separate hoof contact devices are provided where at least one hoof contact device is connected to the front of the hoof support platform and at least one hoof contact device is connected to the first side and at least one hoof contact device is connected with the second side. An attachment device for attaching the hoof protection apparatus to a hoof is provided where the attachment device is removably attached to the hoof protection apparatus.