Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed.

A container for use in growing, culturing and/or modifying cells has a primary container (10) and defines an internal lumen in which a wall element (8) of the primary container (10) is compressible, and wherein the container has an auxiliary container (16) in fluid communication with the primary container (10). The fact that the device has an auxiliary container 16 allows a number of separate reactions to be carried out within a single container.

This invention relates to a packaging and distribution assembly (10) for a fluid product, of the type comprising: a storage member (22), comprising a tubular reservoir (40) able to receive a first fluid composition; a closed chamber (130) in communication with the tubular reservoir; and a pressurization member (24), able to move axially in such a way as to decrease a volume of said closed chamber. The closed chamber is sealed from the air in a deployed configuration of the storage and pressurization members, corresponding to a maximum volume of the closed chamber.

The storage member (22) and the pressurization member (24) comprise means (76) for breaking the seal of the closed chamber in a compact configuration of said storage and pressurization members, said compact configuration corresponding to a minimum volume of the closed chamber.

Shaker will provide users a quicker and more efficient way to take their supplements before, during, and after their workouts. This delivery system will offer them the option to carry all three main supplements at once.

A container apparatus includes a first container and a second container for receipt by the first container. A temporary seal is formed in part by each of the first container and the second container. The temporary seal maintains the second container in the first container. The second container is movable between a first position, in which the temporary seal is engaged, and a second position, in which the temporary seal is disengaged. A lid forms a sealing engagement with the second container to define a lifting mechanism.

A bifurcated bottle, wherein the primary compartment comprises a secondary leading edge disposed circumferentially in the top neck portion of the primary compartment, a primary leading edge disposed vertically above the secondary leading edge in the top neck portion of the primary compartment, and a screw thread finish disposed within the top neck portion of the primary compartment above the primary leading edge. A bifurcating device is affixed to the spout portion of the secondary compartment and situated in the neck portion of the main compartment. The purpose of this is to separate the two liquids or liquid/solid mixture until the time of use.

A closure device for firing an additive into a carbonated beverage bottle with a neck comprises a cap member and a housing. The cap member includes a pressurised tank containing the additive and a propellant and has a bottom aperture. The housing engages with the neck and includes a plug member which engages with the bottom aperture. The cap member can be lifted relative to the housing from a first armed or closed position in which the plug member closes the bottom aperture to a second firing position in which the plug member provides a communication path from the tank through a nozzle in the plug member.

A fluid dispensing bottle cap includes a cap body having a closed top end and an open bottom end. A hollow reservoir is positioned within the interior space of the cap body and is accessible via an aperture that extends through the top end of the cap body. The reservoir is constructed from a resilient material and has a slit along the bottom end for discharging a stored liquid. Another embodiment of the present invention includes a dispensing valve that is positioned within the reservoir body to release a measured amount of the stored liquid upon receiving a pressing force.

Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed.

The present dosure relates to beverage container (10) that includes a lower vessel (12) having a lower vessel neck (16), an upper vessel (22) that is attached to the lower vessel neck (16) and is sized and shaped to hold a liquid therein, a removable cap (40) that is attached to the upper vessel (22), a vessel seal (42) that serves as a liquid- tight barrier between the interior of the upper vessel (22) and the interior of the lower vessel (12), and a tether (44) attached to the vessel seal (42) at one end and the removable cap (40) at the other end. When the removable cap (40) is twisted or removed, it pulls on the tether (44), which pulls and releases the vessel seal (42), thereby allowing liquid from inside the upper vessel (22) to enter the interior of the lower vessel (12).