The present invention relates to an in vitro method for evaluating the risk of chronic obstructive pulmonary disease associated with smoking or inhalation. The method of the present invention comprises: (1) calculating probability P.sub.SMK on the basis of data on the expression of 11 or more genes including at least 11 specific genes from among the following 15 genes in airway epithelial cells exposed to a sample solution containing an aerosol or particulate matter in the aerosol from a tobacco product: TXNIP, EFNA1, CYP1 B1, ADM, AREG, DUSP6, SLC7A11, IGFBP3, WNT5A, CXCR4, PHLDA1, HILPDA, ZBED2, EGLN3, and FBXO32, with use of an intercept and coefficients calculated in advance by logistic regression analysis using public data; (2) calculating probability P.sub.COPD on the basis of data on the expression of 4 or more genes including at least 4 specific genes from among the following 15 genes in airway epithelial cells exposed to a sample solution containing the an aerosol or particulate matter in the aerosol from a tobacco product, with use of coefficients calculated in advance by logistic regression analysis using public data; and (3) calculating the risk of chronic obstructive pulmonary disease associated with smoking or inhalation of the aerosol or particulate matter in the aerosol from the tobacco product from the probability P.sub.SMK and the probability P.sub.COPD.

A cigarette core material capable of being ignited and heated at low temperature for smoking includes 50-95% of slice shreds and 5-50% of cut tobacco by weight percentage. The slice shreds include 40-55% of tobacco film bases, 15-25% of tobacco refined extracts, 0-5% of flavors and fragrances, and 15-30% of smoke additives by weight percentage. The cigarette core material is prepared by mixing the slice shreds with the cut tobacco in a reasonable ratio. The cigarette core material provided by the present invention is able to be heated at low temperature for smoking, and be directly ignited for smoking while the smoking set is out of power, both of which have high-quality sensory experience and can maximize the applicability of cigarette cores. The present invention is a co-product of traditional tobacco and new tobacco. It is also a new product of new market segmentation in the international market.

Disclosed is an aerosol generating system including a cigarette and an aerosol generating device. The cigarette may include a first substrate section and a second substrate section which include a non-tobacco material sheet containing an aerosol generating material, and the aerosol generating device may include a single heater disposed so that a heating area of the first substrate section is different from a heating area of the second substrate section.

A non-combustible aerosol provision system includes an article comprising an aerosol generating material, wherein the aerosol generating material comprises reconstituted tobacco material having a density of less than about 700 milligrams per cubic centimeter and a non-combustible aerosol provision device for heating the aerosol generating material of the article. The non-combustible aerosol provision device includes a coil.

An improved, cleaner functioning smoking article is provided, comprising a aerosol forming substrate engineered to include airflow channels. Features include a hollow tube, which may be comprised of various materials, including the material for vaporization itself, within the engineered material, such as tobacco, for efficient vaporization. Other features include a hollow, inverted cone to permit air ingress in a closed bottomed HNB cigarette, and a capsule cigarette designed to retain loose leaf and original material for clean vaporization.

An article for use in a non-combustible aerosol provision system comprising an aerosol generating material comprising at least one aerosol forming material and a mouthpiece connected to the aerosol generating material, the mouthpiece comprising an upstream end adjacent to the aerosol generating material and a downstream end distal from the aerosol generating material, wherein the mouthpiece comprises a hollow tubular element formed from filamentary tow at the downstream end of the mouthpiece. There is also provided a system including the article and a non-combustible aerosol provision device for heating the aerosol generating material of the article, and a method of manufacturing articles for use in a non-combustible aerosol provision system.

The present disclosure relates to tobacco products, including methodology, devices and compositions, for assisting a smoker to transition from conventional tobacco cigarettes to either e-cigarettes or a tobacco heating device. Provided herein are methodology for switching, along with kits, products and apparatuses.

The present disclosure relates to tobacco products, including methodology, devices and compositions, for assisting a smoker to transition from conventional tobacco cigarettes to either e-cigarettes or a tobacco heating device. Provided herein are methodology for switching, along with kits, products and apparatuses.

A needle-type heater (9) includes a needle-shaped heating body and a heating element (20), wherein: the needle-shaped heating body includes a tapered cap (18) and a heater substrate (19) connected with a bottom of the tapered cap (18); and the heating element (20) is attached to the heater substrate (19) in a way of coated printing. A production method of the needle-type heater (9) and an electrically heated cigarette with the needle-type heater (9) are also provided. The needle-type heater (9) can fully heat a tobacco product, and the tobacco product is easier to be inserted into a heating cavity (8), so that it is convenient to replace the tobacco product and use.

A needle-type heater (9) includes a needle-shaped heating body and a heating element (20), wherein: the needle-shaped heating body includes a tapered cap (18) and a heater substrate (19) connected with a bottom of the tapered cap (18); and the heating element (20) is attached to the heater substrate (19) in a way of coated printing. A production method of the needle-type heater (9) and an electrically heated cigarette with the needle-type heater (9) are also provided. The needle-type heater (9) can fully heat a tobacco product, and the tobacco product is easier to be inserted into a heating cavity (8), so that it is convenient to replace the tobacco product and use.