Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

The present disclosure provides a method of separating α-olefin by a simulated moving bed. The method comprises using a coal-based Fischer-Tropsch synthetic oil as a raw material to obtain a target olefin having a carbon number N within a range from 9 to 18, wherein the raw material is subjected to treatment steps including pretreatment, fraction cutting, alkane-alkene separation, and isomer separation, thereby obtaining a high purity α-olefin product. As compared to conventional rectification and extraction processes, the product obtained by the method of the present disclosure has advantages of higher purity, higher yield, lower energy consumption, and significantly reduced production cost.

The present disclosure provides a method of separating α-olefin by a simulated moving bed. The method comprises using a coal-based Fischer-Tropsch synthetic oil as a raw material to obtain a target olefin having a carbon number N within a range from 9 to 18, wherein the raw material is subjected to treatment steps including pretreatment, fraction cutting, alkane-alkene separation, and isomer separation, thereby obtaining a high purity α-olefin product. As compared to conventional rectification and extraction processes, the product obtained by the method of the present disclosure has advantages of higher purity, higher yield, lower energy consumption, and significantly reduced production cost.

A method of removing THC and/or THCA from a mixture, the mixture including THC and/or THCA and at least one cannabinoid is provided. The method comprises passing a first feedstock stream through a first chromatographic resin arranged in a simulated moving bed (SMB) chromatography configuration to provide a primary raffinate stream, preparing a second feedstock stream, the second feedstock stream comprising the primary raffinate stream or a concentrated primary raffinate stream, and passing the second feedstock stream through a second chromatographic resin to provide an eluate stream, the eluate stream having less than 0.3 wt % THC on a solvent free basis. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

The present invention relates to a method for effectively utilizing fructose raffinate obtained in the process for separating psicose conversion product with a high purity chromatography in the process for preparing psicose, and more specifically, it is utilized for preparation of fructose-containing raw material solution for preparation of psicose by putting fructose raffinate obtained in the process for preparing psicose into the process for preparing fructose.

The invention relates to a process for the chromatographic purification of a starting stream containing ammonium sulfate and 2-hydroxy-2-methylpropionic acid, comprising: passage of the starting stream through a bed of stationary phase; elution of a raffinate enriched in ammonium sulfate and depleted in 2-hydroxy-2-methylpropionic acid; and elution of an extract enriched in 2-hydroxy-2-methylpropionic acid and depleted in ammonium sulfate.

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and cannabis leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the cannabis plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.

The present invention relates to fractionation of crude tall oil, which originates from the Kraft process black liquor. In the method, according to the present invention, simulated moving bed (SMB) chromatography is used to efficiently separate fractions from the crude tall oil.

Method for the simulated moving bed (SMB) separation of a feedstock (F), in which: at least one zone (1, 2, 3, 4) contains fewer than three beds, if the stream (D, E, F, R) delimiting said zone and situated upstream of said zone is injected or withdrawn at the plate P.sub.i via the bypass line L.sub.i/i+1, then the stream delimiting said zone and situated downstream of said zone is injected/withdrawn at the plate P.sub.j via the bypass line L.sub.j/j+1, and if the stream delimiting said zone and situated downstream of said zone is injected or withdrawn at the plate P.sub.i via the bypass line L.sub.i−1/i, then the stream delimiting said zone and situated upstream of said zone is injected/withdrawn at the plate P.sub.j via the bypass line L.sub.j−1/j.

A method of enriching a material comprising glucose, fructose, and one or more components inert to isomerization using chromatography to produce a high purity fructose product. An embodiment of the method purifies high fructose corn syrup from a feedstock into three product streams: a first fraction rich in glucose, a second fructose product comprising an extract of fructose purity exceeding about 95%, and a third less pure fructose fraction comprising fructose ranging from about 55% to about 90% fructose purity. The third less pure fructose fraction may be combined with 42% fructose syrup to produce saleable mid-purity fructose product, such as having 55% fructose purity. An SMB system is also disclosed and comprises a first SMB separator, a second SMB separator, and an isomerization chamber.