The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

The present disclosure relates to a mixer for mixing pasty components, comprising a mixing case extending along a longitudinal axis and having at least one inlet, preferably two inlets, and an outlet, and comprising at least one mixing element received in the mixing case, which defines a plurality of chambers together with the mixing case, said chambers being arranged successively and/or adjacently along a flow path from the inlets to the outlet. The chambers are defined by transverse walls, each extending perpendicularly to the longitudinal axis, and four side walls that each extend parallel to the longitudinal axis, and adjacent chambers are interconnected by a flow by means of through-openings provided in the side walls, the mixing element comprising two strips forming side walls, which are connected by a web that forms other side walls and is perpendicularly arranged in relation to the strips, a first group of chambers having first through-openings arranged in the web, which extend up to a strip, and a second group of chambers comprising second through-openings positioned at a distance to at least one strip in the web.

A heat exchanger comprises a jacket element and an insert element, the jacket element forming a fluid channel for a fluid to be tempered, a flowable medium or a fluid mixture. The insert element is arranged in the fluid channel. The insert element contains a plurality of web elements which are connected to the jacket element at different locations. At least some of the web elements contain web element passages which are in fluid-conducting connection with the jacket element so that, in the operating state, a heat transfer fluid which is fed to the jacket element can flow through the web elements, wherein the jacket element contains a plurality of chambers for a heat transfer fluid, wherein at least one of the chambers is disposed with a plurality of inlet openings and outlet openings for the heat transfer fluid.

A portioning machine for providing a custom cosmetic includes a mixer having a mixing chamber and also accommodates a plurality of dispensers having outlets that are directly coupled to the mixing chamber. In one embodiment, the portioning machine includes a plurality of slots, where each slot is configured to receive an assembly having at least one dispenser. In another embodiment, the portioning machine includes a slot configured to receive an assembly having a plurality of dispensers. Each dispenser is associated with an actuator, and the portioning machine includes a portioning processor configured to control the actuators to dispense additives from selected dispensers into the mixing chamber in accordance with a target set of additive ratios to produce the custom cosmetic.

A vortexing chamber, including: a chamber housing having a hollow channel, a first end and a second end; and one or more structural impediment objects having a substantially spherical, cubic, rectangular, cylindrical, polyhedron, tetrahedron, or irregular shape; where the objects are housed within the hollow channel, configured to mix a liquid and gas (for example, oxygen or nitrogen) when a liquid and gas pass through the vortexing chamber. The structural impediment objects can provide turbulence and dispersion when a liquid and gas are passed through the vortexing chamber at a high velocity, resulting in micro-bubbles or nano-bubbles suspended in a liquid and gas mixture.

A device to be installed in a pipeline, characterized by at least one static mixer and at least one pre-mixer arranged in a sleeve, wherein said at least one static mixer is characterized by: a body having a plurality of slots through the body, said slots having one or more sides that are angled with respect to an axis passing through a center of the body; a plurality of arms extending from an outer edge of the body towards a center of the body, wherein the plurality of slots comprising at least one concentric ring of slots.

A mixing inclined belt conveyor capable of mixing particulate material, specifically wet, freshly treated plant seeds for agricultural purposes. Inserting a plurality of mixing baffles into the stream of the particulate material induces a backflow of the particulate material. In the case of wet, freshly treated plant seed, this backflow causes a mixing, polishing, and drying of the plant seed. The mixing distributes the seed treatment into an even coat by rubbing the individual seeds of the seed flow stream together. The mixing baffles are oriented to induce backflow and sideways lateral movement and may incorporate a passage to allow increase material flow rate.

A conveyor having a conveyance structure, belt, and gas manifold. The gas manifold disposed within or on an exterior portion of the structure. The gas manifold having one or more manifold outlet ports to dry, condition, or treat a metered stream of seed within the conveyor. The manifold may be operably connected to a recirculating air system providing the vacuum source and pressurized air source of atmospheric or conditioned air. A filter and vacuum port may extract debris or humidity from the metered stream of seed within the conveyor. A plurality of mixing baffles may be longitudinally spaced apart through the conveyor in a laterally alternating manner to mix the metered stream of seed. The conveyor may be used to transfer, mix, dry, condition and treat the metered stream of seed between multiple stages of treatment.

A flow disturbance apparatus includes: a refrigerant pipe having a flow space in which refrigerant flows; and at least one disturbance member disposed inside the refrigerant pipe that is vibrated by the flow of refrigerant in the refrigerant pipe to disturb the refrigerant flowing in the refrigerant pipe.

A mixer insert (1) for a static mixer, comprising a plurality of mixing elements (3, 3a, 3b, 3c, 3d, etc.) which are disposed one behind the other along a longitudinal axis (L) and preferably immediately adjoin each other and each comprise a plurality of crossing rods (8, 9; 10, 11), at least two mixing elements consecutive along the longitudinal axis (L) among the plurality of mixing elements (3, 3a, 3b; 3b, 3c; 3c, 3d; etc.) being turned relative to each other by a twist angle of preferably 90 with respect to the longitudinal axis (L), the mixer insert (1) being composed of multiple separate mixer-insert parts (2, 2a, 2b) which each extend along the longitudinal axis and which are disposed adjacent to each other perpendicular to the longitudinal axis (L), each mixer-insert part (2, 2a, 2b) having a plurality of mixing-element parts (14, 14a, 14b, 14c, 14d, etc.; 15, 15a, 15b, 15c, 15d, etc.) which are disposed one behind the other along the longitudinal axis (L) and are integrally connected to each other along the longitudinal axis (L) and immediately adjoin each other, and that the mixing-element parts (14, 15; 14a, 15a; 14b, 15b; 14c, 15c, 14d, 15d; etc.) of the mixer-insert parts (2, 2a, 2b) that are disposed next to each other perpendicular to the longitudinal axis form one of the mixing elements (3, 3a, 3b, 3c, 3d, etc.), and that at least two of the mixing-element parts (14, 14a, 14b, 14c, 14d, etc.; 15, 15a, 15b, 15c, 15d, etc.) of the mixer-insert parts (2, 2a, 2b) that immediately adjoin each other along the longitudinal axis (L) are turned relative to each other by the twist angle with respect to the longitudinal axis (L).