Disclosed herein are fluidic mixers having bifurcated fluidic flow through toroidal mixing elements. The mixers operate, at least partially, by Dean vortexing. Accordingly, the mixers are referred to as Dean Vortex Bifurcating Mixers (DVBM). The DVBM utilize Dean vortexing and asymmetric bifurcation of the fluidic channels that form the mixers to achieve the goal of optimized microfluidic mixing. The disclosed DVBM mixers can be incorporated into any fluidic (e.g., microfluidic) device known to those of skill in the art where mixing two or more fluids is desired. The disclosed mixers can be combined with any fluidic elements known to those of skill in the art, including syringes, pumps, inlets, outlets, non-DVBM mixers, heaters, assays, detectors, and the like.

A fluid supply pipe according to an embodiment of the invention includes an internal structure and a pipe body configured to house the internal structure. The pipe body has an inlet and an outlet and has a circular cross-section. The internal structure includes a first portion for diffusing a fluid flowing into the fluid supply pipe through the inlet radially from the center of the fluid supply pipe, the first portion being placed in the inlet side of the pipe body when the internal structure is housed in the pipe body, a second portion placed downstream from the first portion and including a plurality of spiral vanes to swirl the fluid diffused by the first portion, and a third portion placed downstream from the second portion and including a plurality of protrusions on its outer circumferential surface.

A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.

A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.

A static mixer for use with biopharmaceutical compositions includes a shell and a core. The shell defines a flow channel therethrough. The shell is formed as a lattice structure that defines a plurality of voids in fluid communication with the flow channel. The core is disposed within the flow channel of the shell. The core is configured to mix a first fluid and a second fluid together as the first fluid and the second fluid flow through the flow channel. The first fluid or the second fluid is a biopharmaceutical composition.