An improved apparatus for oligonucleotide synthesis, that has four or more synthesis vessels, each synthesis vessel having a waste emitting end, a synthesis plate holding the four or more synthesis vessels, a drain block located below and coupled to the synthesis plate, a sealing device in contact with the synthesis plate and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating the exterior of the drain block and the waste collection reservoir(s), one or more waste tubes connected to the waste collection reservoir(s), each waste tube comprising a waste valve. The sealing device may have one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. Each equilibration hole may be coupled to a solenoid or flow control valve.

A process for polymerizing or copolymerizing ethylenically unsaturated monomers in the presence of free-radical polymerization initiators, wherein the polymerization is carried out at temperatures from 100? C. to 350? C. and pressures in the range of from 110 MPa to 500 MPa in a continuously operated polymerization reactor which is controlled by a pressure control valve at the outlet of the polymerization reactor, the process comprising continuously monitoring the pressure within the polymerization reactor, feeding a pressure signal to a controller for controlling the control valve and having the controller altering the opening of the pressure control valve to control the pressure within the polymerization reactor, wherein the controller starts an emergency shutdown program when the pressure control valve closes more than a preset threshold value and the pressure within the polymerization reactor decreases below a preset pressure threshold.

A process for polymerizing or copolymerizing ethylenically unsaturated monomers in the presence of free-radical polymerization initiators, wherein the polymerization is carried out at temperatures from 100 C. to 350 C. and pressures in the range of from 110 MPa to 500 MPa in a continuously operated polymerization reactor which is controlled by a pressure control valve at the outlet of the polymerization reactor, the process comprising continuously monitoring the pressure within the polymerization reactor, feeding a pressure signal to a controller for controlling the control valve and having the controller altering the opening of the pressure control valve to control the pressure within the polymerization reactor, wherein the controller starts an emergency shutdown program when the pressure control valve closes more than a preset threshold value and the pressure within the polymerization reactor decreases below a preset pressure threshold.

The invention relates to a device (1) for evaluation of at least one performance criterion of heterogeneous catalysts, comprising; at least one reactant source (2), at least one reaction zone equipped with at least one catalyst and connected to at least one reactant source (2) in such a way as to produce, in each reaction zone, a heterogeneous catalytic reaction between each catalyst present in the reaction zone and the reactant or reactants coming from each reactant source (2) connected to the reaction zone, and means for evaluation of at least one performance criterion of heterogeneous catalysts, characterized in that the device (1) further comprises a gas chromatograph and in that each reaction zone (9) is situated in an injector (8) of the gas chromatograph.

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyzes requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyzes.

The invention relates to a device and a method for the generation of molecular microarrays. The invention relates therefore to a universal approach for the generation of protein microarrays, DNA microarrays and RNA microarrays (in general nucleic acid microarrays), by production of an output molecule from a template molecule microarray via enzymatic or chemical processes and transfer of the output molecule onto the desired molecular microarray.

The invention relates to a container holder 10, comprising a main body 12 which in turn comprises a gas inlet 16; a solution liquid outlet 18; a gas control valve 20 through which a gas enters the container 100 from the gas inlet; and a sealing means 22 for the container, which sealing means includes a passageway 24 for the input of gas and output of a solution in the container via an egress tube 19; wherein when the container is connected to the container holder through the sealing means, the gas control valve opens automatically, and when the container is disconnected the gas control valve is closed automatically. The invention further relates to a container panel 50 which includes two or more container holders. Also disclosed are methods of using these containers and container panels for synthesizing a polypeptide.

An improved apparatus for oligonucleotide synthesis that reduces reagent consumption and increase yield, typically comprising one or more synthesis vessels, each having a waste emitting end, a drain block located below and operably coupled to the synthesis vessel(s), a sealing device disposed between the synthesis vessel(s) and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating an exterior of the drain block and the waste collection reservoir(s), one or more waste tubes leading from the waste collection reservoir(s), each waste tube comprising a waste valve. In some embodiments the sealing device may comprise one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. In some embodiments, each equilibration hole may be operably coupled to a solenoid or flow control valve.

A method for shutting down a gas treatment plant to minimize flaring and allow for continued production during the shutdown procedure. The method includes reducing a sour gas feed flow rate and monitoring pressures in headers for various process units to identify when pressure equalization occurs. The method includes sampling the rich solvent in the system to verify a setpoint concentration of hydrogen sulfide has been reached to initiate a final system shutdown.

Provided is a full-automatic radiopharmaceutical production apparatus including a synthesis device. The synthesis device includes a synthesis cassette and a main synthesis unit. The synthesis cassette includes a synthesis cassette body. The synthesis cassette body includes a first common pipe extending in a left-right direction. The first common pipe is located between three-way valves that are adjacent in the left-right direction. The main synthesis unit includes a main synthesis unit frame. The first common pipe is detachably fixed at a front housing of the main synthesis unit frame by a first fixing assembly.