The present invention relates to a dual-chamber pack for a multi-dose oral liquid pharmaceutical composition wherein the compositions of the first and second chambers are mixed at the time of first administration.

A container for mixing two fluids includes: a container, a pouring cylinder; an upward facing step portion, a cap whose inner circumferential surface is screwed onto an outer circumferential surface of the pouring cylinder, a small container placed on an inner side of the cap; a cuttable first sheet that forms a bottom surface of the small container, a removable cylinder provided at a bottom end of the cap and interposed between the cap and the upward facing step portion, and a first cutter that is provided on the container so as to face a bottom surface of the small container that is placed on the inner side of the cap. The small container is made to approach the first container, and the first sheet is then cut by the first cutter.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

A containment device for biological samples, which comprises: a first vessel for depositing a biological sample, a lid adapted to engage the first vessel, a hermetically-sealed chamber, adapted to contain a preservative, arranged between the lid and the first vessel, elements of generating a passage between the hermetically-sealed chamber and the first vessel for the descent of the preservative from the chamber to the first vessel; the hermetically-sealed chamber is defined by a second vessel, which is inserted into the first vessel with the filling opening directed toward the lid, and by the lid itself, closed onto the first vessel, the elements of generating a passage between the hermetically-sealed chamber and the first vessel comprise a region with a pre-fracture that is defined on the second vessel and a corresponding presser that extends from the lid and is in a position to encounter the region with a pre-fracture.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

A dispensing system provides for the delivery of a contained substance sealed in a Dispensable Containment Vessel (DCV) into a target container, which can contain another substance. The dispensing system includes a dispensing adaptor (Dispensing System) that couples the DCV to the target container so substances can be transferred between the containers without escaping or contacting the user. When the DCV is activated from a secure conformation into a dispensing conformation, the dispensing adaptor sealably engages the target container and portions of the dispensing adaptor place stress on a barrier, which frangibly tears along defined tearing paths to form vents or flaps that are forced apart against the dispensing adaptor, allowing the contents of the DCV to enter the target container. The dispensing conformation also facilitates the efficient mixture of substances and allows them to travel between the containers to flush residual DCV contents into the target container.

The metering device includes a metering container which can be fitted with screwing action on a standard bottle neck. The metering container has a funnel-shaped base, which is adjoined by a cylindrical lateral wall having, at the upper end, a cross-sectionally u-shaped collar, to which a cover surface can be applied in a form-fitting manner. At the top of the metering device is a pressure-exerting head with an encircling, detachable periphery. A puncturing mechanism having a two-part pressure-exerting pin can be actuated by the pressure-exerting head. The puncturing mechanism is fixed to the cover surface, prior to initial use, and is separated out of the cover surface by a cylindrical casing wall on the pressure-exerting head. The second part of the puncturing mechanism has a punching sleeve, which severs membranes which close the metering container, whereupon the contents of the metering container can be supplied into the bottle.

An apparatus and method are provided for storing and dispensing into a liquid a soluble substance, such as a flavoring, a body fuel, a nutritional supplement, a stimulant, a relaxant, an alcohol neutralizer, or a medical drug. A useful application of the subject invention includes a lime flavoring held by a gelatinous artificial lime wedge stored with a beer bottle or can, or attached to a 6-pack or 12-pack carton. The artificial lime wedge may be retrieved from a protective covering and acted upon so it mixes the lime flavoring into the beer when it is inserted into the beer bottle or can. Rather than needing to buy and store a perishable natural lime, and cut it up, an artificial lime wedge may be stored for an extended period of time with a beer vessel and placed in functional contact with the beer at time of consumption.

Disclosed herein is a package having: a housing defining a body and a container; a frangible closure which, in combination with the body, defines a soluble compartment; a frangible closure which, in combination with the container, defines a water compartment separate from the soluble compartment; a quantity of a soluble contained within the soluble compartment; and a quantity of water contained within the water compartment and which, if mixed with the soluble contained in the soluble compartment, produces an ingestible.

A closure capsule for closing a container, comprising: —a stopper (2) applicable to the container and comprising a first perforable membrane (21); —a first cutter (31) of the first membrane, said first cutter (31) being movable between a start stroke position and an end stroke position; in the start stroke position of the first cutter (31), in combination with at least the first membrane (21), the first cutter (31) delimits a first tank (41) for containing a first substance; in the end stroke position of the first cutter (31) at least a part of the first membrane (21) being perforated to enable passage of the first substance from the first tank (41) to the container. The stopper (2) comprises at least a second perforable membrane (22). The capsule (1) comprises a second cutter (32) for cutting the second membrane, said second cutter (32) being movable between a start stroke position and an end stroke position; in the start stroke position of the second cutter (32), in combination with at least the second membrane (22), the second cutter (32) delimiting a second tank (42) for containing a second substance; in the end stroke position of the second cutter (32) at least a part of the second membrane (22) being perforated and enabling passage of the second substance from the second tank (42) to the container.