Provided are anti-microbial compositions that include an aqueous solution of hypochlorous acid encapsulated in a nanoparticle that allows for controlled release of hypochlorous acid. Also provided are methods of making and using such compositions.

Provided are anti-microbial compositions that include an aqueous solution of hypochlorous acid encapsulated in a nanoparticle that allows for controlled release of hypochlorous acid. Also provided are methods of making and using such compositions.

A method for making an aqueous hypochlorous acid (HClO) solution includes electrolyzing a solution of sodium chloride to produce a solution of sodium hypochlorite; and producing the aqueous hypochlorous acid solution by adjusting a pH of the solution of sodium hypochlorite to a value within a range of 3 to 8 by adding a selected weak acid to the solution of sodium hypochlorite to produce a buffer including the selected weak acid and a salt of the selected weak acid.

A method for making an aqueous hypochlorous acid (HClO) solution includes electrolyzing a solution of sodium chloride to produce a solution of sodium hypochlorite; and producing the aqueous hypochlorous acid solution by adjusting a pH of the solution of sodium hypochlorite to a value within a range of 3 to 8 by adding a selected weak acid to the solution of sodium hypochlorite to produce a buffer including the selected weak acid and a salt of the selected weak acid.

An apparatus assembly and method for the electrolytic production of a hypochlorous (HOCl) acid solution are disclosed. A first controlled amount of water, such as tap water, a second controlled amount of an acidic solution (acetic acid or CH.sub.3COOH), and a third controlled amount of a sodium chloride (NaCl) solution, preferably from a brine solution, are mixed by injecting the same in a reaction loop comprising an electrolytic reactor configured to electrolyze the mixture into the HOCl solution. Preferably, the electrolytic reactor comprises DSA (dimensionally stable anodes). The mixture is circulated in the reaction loop until the HOCl solution is formed. The assembly can be monitored in real-time and remotely for quality control. The disinfecting solution as produced comprises 330-460 ppm HOCl at a pH between 5 and 6, preferably at a pH of 5.5, the solution being stable at least up to 6 months after being produced.

An apparatus assembly and method for the electrolytic production of a hypochlorous (HOCl) acid solution are disclosed. A first controlled amount of water, such as tap water, a second controlled amount of an acidic solution (acetic acid or CH.sub.3COOH), and a third controlled amount of a sodium chloride (NaCl) solution, preferably from a brine solution, are mixed by injecting the same in a reaction loop comprising an electrolytic reactor configured to electrolyze the mixture into the HOCl solution. Preferably, the electrolytic reactor comprises DSA (dimensionally stable anodes). The mixture is circulated in the reaction loop until the HOCl solution is formed. The assembly can be monitored in real-time and remotely for quality control. The disinfecting solution as produced comprises 330-460 ppm HOCl at a pH between 5 and 6, preferably at a pH of 5.5, the solution being stable at least up to 6 months after being produced.

The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.

The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.

Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.

Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release.