The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. ##STR00001##

The present invention provides a production method of a 3-cyanopyrrole compound possibly useful as an intermediate for pharmaceutical products. A production method of compound (II) including subjecting compound (I) to a reduction reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. A production method of compound (III) including subjecting compound (I) to a reduction reaction followed by a cyclization reaction, in which the aforementioned reduction reaction is continuous hydrogenation reaction in a fixed bed reactor filled with a supported metal catalyst. ##STR00001##

Diphosphites having an open and a closed 2,4-methylated outer unit and use thereof in hydroformylation.

Diphosphites having an open and a closed 2,4-methylated outer unit and use thereof in hydroformylation.

The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.

The present invention relates to a method for producing an aldehyde by a hydroformylation reaction of reacting an olefin with hydrogen and carbon monoxide in the presence of a Group 8 to 10 metal-phosphine complex catalyst, including the following steps (1) and (2): (1) a step of oxidizing by withdrawing a reaction solution having accumulated therein a high-boiling-point byproduct from a reaction zone and bringing the withdrawn reaction solution into contact with an oxygen-containing gas, and (2) a step of, after the step (1), mixing a poor solvent and hydrogen with the reaction solution, then crystallizing the Group 8 to 10 metal-phosphine complex catalyst by crystallization, and recovering the crystallized complex catalyst from the reaction solution.

The present invention relates to a method for producing an aldehyde by a hydroformylation reaction of reacting an olefin with hydrogen and carbon monoxide in the presence of a Group 8 to 10 metal-phosphine complex catalyst, including the following steps (1) and (2): (1) a step of oxidizing by withdrawing a reaction solution having accumulated therein a high-boiling-point byproduct from a reaction zone and bringing the withdrawn reaction solution into contact with an oxygen-containing gas, and (2) a step of, after the step (1), mixing a poor solvent and hydrogen with the reaction solution, then crystallizing the Group 8 to 10 metal-phosphine complex catalyst by crystallization, and recovering the crystallized complex catalyst from the reaction solution.

The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.