Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.

The present invention provides a palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). ##STR00001## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24, m, E and X are described in the specification. The invention also provides a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.

The present invention provides a palladium(II) complex of formula (1) or a palladium(II) complex of formula (2). ##STR00001## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24, m, E and X are described in the specification. The invention also provides a process for the preparation of the complexes, and their use in carbon-carbon and carbon-heteroatom coupling reactions.

The present invention relates to the use, as a fluorescent chromophore, of a compound with formula (I) wherein: A.sub.1 is N or C(Y.sub.1); A.sub.2 is N or C(Y.sub.2); A.sub.3 is N or C(Y.sub.3); A.sub.4 is N or C(Y.sub.4); at least one of A.sub.1, A.sub.2, A.sub.3 and A.sub.4 representing N; X.sub.1 is N or C(Y.sub.5); X.sub.2 is N or C(Y.sub.6); X.sub.3 is N or C(Y.sub.7); and Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Y.sub.5, Y.sub.6 and Y.sub.7 are in particular chosen independently of one another from the group made up of: H, electron-donor groups and electron-attracting groups.

The present invention relates to the use, as a fluorescent chromophore, of a compound with formula (I) wherein: A.sub.1 is N or C(Y.sub.1); A.sub.2 is N or C(Y.sub.2); A.sub.3 is N or C(Y.sub.3); A.sub.4 is N or C(Y.sub.4); at least one of A.sub.1, A.sub.2, A.sub.3 and A.sub.4 representing N; X.sub.1 is N or C(Y.sub.5); X.sub.2 is N or C(Y.sub.6); X.sub.3 is N or C(Y.sub.7); and Y.sub.1, Y.sub.2, Y.sub.3, Y.sub.4, Y.sub.5, Y.sub.6 and Y.sub.7 are in particular chosen independently of one another from the group made up of: H, electron-donor groups and electron-attracting groups.

Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstituted benzotriazole phenol by coupling reactions. The ortho substituent group can be a simple alkoxy or amino group, or the ortho substituent group can be a linking group, linking the benzotriazole phenol to another benzotriazole phenol group.

Benzotriazole phenols with substituents either ortho to the phenol hydroxyl group and/or para to the phenol hydroxyl group can be prepared from the unsubstituted benzotriazole phenol by coupling reactions. The ortho substituent group can be a simple alkoxy or amino group, or the ortho substituent group can be a linking group, linking the benzotriazole phenol to another benzotriazole phenol group.

Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.

Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.