The present disclosure provides a method for preparing a deuterated organic compound in good yield even though a reduced amount of benzene-D6 is used by using a solvent comprising a benzene-based compound not substituted with deuterium or partially substituted with deuterium.

A compound including a first ligand L.sub.A of Formula I,

##STR00001##

is described. In Formula I, each of X.sup.1 to X.sup.9 is independently C or N; one of Z.sup.1 and Z.sup.2 is C and the other is N; each of K.sup.1 and K.sup.2 is independently a direct bond, O, or S; at least one of K.sup.1 and K.sup.2 is a direct bond; at least one R.sup.B is not hydrogen; R.sup.3 is selected from alkyl, heteroalkyl, cycloalkyl, and heterocycloalkyl; L.sub.A is coordinated to a metal M; at least one of the following is true: (i) at least one R.sup.B comprises a 5- or 6-membered, (ii) two adjacent R.sup.B are joined to form a fused 5- or 6-membered ring, or (iii) R.sup.B comprises a carbocyclic or heterocyclic ring substituted with at least one electron withdrawing group. Devices, consumer products, and formulations including the compound are also described.

The present disclosure provides for an organic electroluminescent device (OLED) including an anode; a cathode; and an emissive layer, disposed between the anode and the cathode. The emissive layer includes a phosphorescent dopant, a first host, and a second host, wherein the first host transports holes, the second host transports electrons, and the first host is fully or partially deuterated. Consumer products that include the OLED are also provided.

Provided is a compound of Formula 1:

##STR00001## wherein: X and Y are independently O, S, or CZ1Z2; Ring A is a benzene or naphthalene ring; A1 to A4 are independently hydrogen, deuterium, a halogen group, a cyano group, a nitro group, a hydroxyl group, or a substituted or unsubstituted: alkyl, cycloalkyl, aryl, or heterocyclic group; R1 to R6, Z1, and Z2 are independently a substituted or unsubstituted: alkyl, aryl, or heterocyclic group; n1 to n3, m, and l are 0 or 1 and n1+n2+n3 is ≥2; a1 and a2 are 1 to 4; a3 is 1 to 3; a4 is 1 to 6; and when a1 to a4 are each 2 or higher, structures in the parenthesis are the same or different, provided that when Ring A is naphthalene, m is 0, and when l is 1, Ring A is a benzene ring,
and an organic light-emitting device comprising the compound.

A compound, a composition for an organic optoelectronic device, an organic optoelectronic device, and a display device, the compound being represented by Chemical Formula 1:

##STR00001##

An organic compound is disclosed comprising: a first chemical moiety with a structure of formula I

##STR00001##

and two second chemical moieties, independently from another with a structure of formula II,

##STR00002##

wherein the first chemical moiety is linked to each of the two second chemical moieties via a single bond.

A macrocycle represented by formula (I) and a pharmaceutical composition comprising the macrocycle, or a crystalline form, pharmaceutically acceptable salt, hydrate or solvent compound, stereoisomer, prodrug, or isotopic variant of the macrocycle. The macrocycle and the composition thereof inhibit a protein kinase.

An organic electroluminescence device includes an anode, a cathode, and an emitting layer disposed between the anode and the cathode. The emitting layer comprises a delayed fluorescent compound M2 having at least one deuterium atom and a compound M3 having at least one deuterium atom. A singlet energy S.sub.1(M2) of the compound M2 and a singlet energy S.sub.1(M3) of the compound M3 satisfy the relationship S.sub.1(M3)>S.sub.1(M2).

An organic electroluminescence device includes: an anode; a cathode; a first emitting layer; and a second emitting layer provided between the first emitting layer and the cathode, in which the first emitting layer contains, as a first host material, a first compound that has at least one group represented by a formula (11) below and that is represented by a formula (1) below, the second emitting layer contains, as a second host material, a second compound represented by one of formulae (2-1A) to (2-4A) below, and the first emitting layer and the second emitting layer are in direct contact with each other.

##STR00001## ##STR00002##

Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.