Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

The present invention relates to a process for producing an organic fluoro compound containing [.sup.18F]fluorine. The method of the present invention for producing the organic fluoro compound is not only advantageous for producing the organic fluoro compound with high yield by using the solvent represented by formula 1 for nucleophilic fluorination reaction but also suitable for automatic synthesis of .sup.18F-labeled radiopharmaceuticals due to the excellent solubility of the precursor compound in the solvent.

The present invention is directed towards new .sup.18F-folate radiopharmaceuticals, wherein the .sup.18F isotope F is linked via a prosthetic group, more specifically via a prosthetic group having a saccharide group, such as a cyclic mono- or oligosaccharide, preferably based on a pyranoside or furanoside, which is covalently linked to the glutamate portion of a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Disclosed herein, inter alia, are compounds, compositions, and methods of synthesizing labeled nucleosides.

Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

Described herein are compositions and methods for diagnosing, imaging, and quantifying non-calcified atherosclerotic plaque. Embodiments of compositions described herein comprise mannosylated dextran compounds along with other carbohydrate molecules comprising, for example, a diagnostic agent and a diagnostic moiety. The compounds and methods embodied herein produce superior localization and results for imaging, anatomically locating, and quantifying non-calcified atherosclerotic plaque.

Disclosed are a series of deuterated nucleoside compounds and a use thereof. Specifically disclosed are compounds represented by formula (VI-2), and stereoisomers or pharmaceutically acceptable salts thereof.

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Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.

This disclosure relates to using 3-iodopropyl-1,2,3-triazol-1-yl or 3-bromopropyl-1,2,3-triazol-1-yl as linking groups for generating labeled conjugates. In certain embodiments, disclosure relates to using 3-iodopropyl-1,2,3-triazol-1-yl or 3-bromo-propyl-1,2,3-triazol-1-yl as linking groups for generating labeled polysaccharide conjugates or derivatives. In certain embodiments, this disclosure relates to methods of generating radionuclides.