Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease.

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The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.

The present specification relates to a composition including two or more compounds represented by Chemical Formula 1 and having a different number of deuterium substitution, wherein, in the composition, the number of deuterium of an isotope having a highest isotope content among each isotope content for each mass number of the two or more compounds having a different number of deuterium substitution is 13 or greater, and an electronic device and an organic light emitting device including the same.

An organic compound and an organic light emitting device including the same are disclosed. For example, an organic compound is represented by the following chemical formula in which one of X1 and X2 is N, and the other one of X1 and X2 is O or S. The organic light emitting diode and the organic light emitting device each includes the organic compound.

##STR00001##

A light emitting device and a light emitting display device that are capable of improving efficiency, driving voltage, and lifespan by varying the configuration of a layer adjacent to a blue light emitting layer in a blue fluorescent stack contacting a cathode are disclosed. The light emitting device includes stacks between an anode and a cathode, wherein an n.sup.th stack contacting the cathode is a first blue stack that includes a first hole transport layer, a first electron-blocking layer, a first blue light emitting layer containing a boron-based dopant having an emission peak of 430 nm to 480 nm, a first electron transport layer contacting the first blue light emitting layer, and an electron injection layer having two sides contacting the first electron transport layer and the cathode, respectively, wherein the first electron transport layer contains a mixture of a first material and a second material.

A light emitting element that includes a first electrode, a second electrode, and an emission layer between the first electrode and the second electrode is provided. The emission layer includes a polycyclic compound represented by Formula 1. The light emitting element shows a high emission efficiency and long-life characteristics.

##STR00001##

A light emitting element that includes a first compound represented by a specific chemical formula in which an ortho-type or kind penta-phenyl group is bonded to a fused polycyclic compound including at least one boron atom and a heteroatom is provided. The light emitting element has a long-lifetime.