Disclosed herein are amphiphilic surfactants which comprise a polymer chain having a hydrophobic unit and hydrophilic unit wherein the polymer is tethered to an inorganic nanoparticle. Further disclosed are methods for preparing the disclosed amphiphilic surfactants.

A solid support for use in non-aqueous DNA-conjugated molecule reactions, wherein the support comprises a solid body formed from a plurality of polyethylene glycol units, wherein the solid body includes at least one cationic moiety.

The present invention relates to a compound of formula (I) below:

##STR00001##

in which:

R.sub.1 represents, in particular, an alkylene group comprising from 1 to 6 carbon atoms;

R.sub.2 and R.sub.3 are, in particular, H;

n is 0, 1, 2 or 3; and R.sub.4 is chosen from the group consisting of: NO.sub.2, OR.sub.a, SR.sub.a and NR.sub.aR.sub.b, wherein R.sub.a and R.sub.b are as defined above;

R.sub.5 and R.sub.6, identical or different, represent an alkyl or alkoxy group comprising from 1 to 6 carbon atoms; and

R.sub.7, R.sub.8 and R.sub.9, identical or different, represent an alkyl group comprising from 2 to 6 carbon atoms.

The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2-substituted nucleotides, such as 2-O-methyl or 2-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.

Biotin derivatives, methods of using the biotin derivatives and kits comprising the biotin derivatives.

The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.

Multi-biotinylated reactants are provided which can be used in divalent complexes for various applications such as colocalization, labeling, immobilization, and purification. Methods for constructing, purifying, and using the bis-biotinylated reactants are also provided. In certain embodiments, two bis-biotinylated reactants are bound to a single streptavidin tetramer to provide a complex having a 1:1 stoichiometry with respect to the bis-biotinylated reactants.

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the OH group at the 3-position of the deoxyribose.

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the OH group at the 3-position of the deoxyribose.

Provided herein is a multitarget-directed bio-inorganic hybrid structure. The hybrid structure is based on carbon nanotubes, and includes: carbon nanotubes; and two or more peptides bound to a surface of the carbon nanotubes and each independently interacting with different target molecules.