C07C37/50

Manufacturing and purification technology for high purity Propofol
11767281 · 2023-09-26 ·

A process for manufacturing Pure Propofol with a purity of more than 99.90% is disclosed, said process comprising dissolving Crude Propofol in a solvent in which it is soluble to form a solution, treating the solution with aqueous alkali to form an aqueous alkali layer and a solvent layer, separating the aqueous alkali layer from the solvent layer using a phase separation technique, distilling off the solvent from the solvent layer, and distilling a residue of the solvent containing Propofol using steam or boiling water in a presence of dilute alkali and antioxidant like metabisulfite, under normal pressure or mild vacuum.

Manufacturing and purification technology for high purity Propofol
11767281 · 2023-09-26 ·

A process for manufacturing Pure Propofol with a purity of more than 99.90% is disclosed, said process comprising dissolving Crude Propofol in a solvent in which it is soluble to form a solution, treating the solution with aqueous alkali to form an aqueous alkali layer and a solvent layer, separating the aqueous alkali layer from the solvent layer using a phase separation technique, distilling off the solvent from the solvent layer, and distilling a residue of the solvent containing Propofol using steam or boiling water in a presence of dilute alkali and antioxidant like metabisulfite, under normal pressure or mild vacuum.

Silylations of aromatic substrates with base-activated organosilanes

The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

Silylations of aromatic substrates with base-activated organosilanes

The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

Silylations of aromatic substrates with base-activated organosilanes

The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.

PROCESS FOR PREPARING A HYDROXY COMPOUND BY MEANS OF DECARBOXYLATION
20220017441 · 2022-01-20 ·

The invention relates to a process for preparing a specific hydroxy compound by means of decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound, to a method for preparing a diaryl carbonate, a bisphenol or a polycarbonate, a diaryl carbonate or bisphenol, a polycarbonate, and to a method for adjusting the isotope ratio of C14 to C12 in a polymer. A specific solvent is used during decarboxylation.

PROCESS FOR PREPARING A HYDROXY COMPOUND BY MEANS OF DECARBOXYLATION
20220017441 · 2022-01-20 ·

The invention relates to a process for preparing a specific hydroxy compound by means of decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound, to a method for preparing a diaryl carbonate, a bisphenol or a polycarbonate, a diaryl carbonate or bisphenol, a polycarbonate, and to a method for adjusting the isotope ratio of C14 to C12 in a polymer. A specific solvent is used during decarboxylation.

PROCESS FOR PREPARING A HYDROXY COMPOUND BY MEANS OF DECARBOXYLATION
20220017441 · 2022-01-20 ·

The invention relates to a process for preparing a specific hydroxy compound by means of decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound, to a method for preparing a diaryl carbonate, a bisphenol or a polycarbonate, a diaryl carbonate or bisphenol, a polycarbonate, and to a method for adjusting the isotope ratio of C14 to C12 in a polymer. A specific solvent is used during decarboxylation.

METHOD FOR PRODUCING A HYDROXY COMPOUND BY DECARBOXYLATION IN THE PRESENCE OF A BRONSTED BASE
20220017442 · 2022-01-20 ·

The invention relates to a method for producing a specific hydroxy compound by decarboxylating a specific carboxylic acid compound or a salt of said carboxylic acid compound in the presence of a Bronsted base. The invention also relates to a method for producing a diaryl carbonate or a bisphenol, to a method for producing a polycarbonate and to a use of a Bronsted base during the reaction of the decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound.

METHOD FOR PRODUCING A HYDROXY COMPOUND BY DECARBOXYLATION IN THE PRESENCE OF A BRONSTED BASE
20220017442 · 2022-01-20 ·

The invention relates to a method for producing a specific hydroxy compound by decarboxylating a specific carboxylic acid compound or a salt of said carboxylic acid compound in the presence of a Bronsted base. The invention also relates to a method for producing a diaryl carbonate or a bisphenol, to a method for producing a polycarbonate and to a use of a Bronsted base during the reaction of the decarboxylation of a specific carboxylic acid compound or a salt of said carboxylic acid compound.