The invention provides a plurality of methods which may be employed as a single method or a plurality of sequential method steps in the isolation and purification of Cannabidiol from Hemp plants. It also provides methods for having a terpene-rich fraction as a byproduct of the method. Depending upon the ultimate objective, the individual method components may be used separately or combined with one or more method steps to accomplish the objectives.

The invention provides a plurality of methods which may be employed as a single method or a plurality of sequential method steps in the isolation and purification of Cannabidiol from Hemp plants. It also provides methods for having a terpene-rich fraction as a byproduct of the method. Depending upon the ultimate objective, the individual method components may be used separately or combined with one or more method steps to accomplish the objectives.

Some variations provide a system for extracting a product from biomass, comprising: a process chamber having an internal volume; one or more mechanical elements configured to controllably and reversibly mechanically seal the process chamber and reduce the internal volume to mechanically compress the biomass; a fluid port in flow communication with the process chamber; and a collection sub-system in flow communication with the fluid port. Other variations provide a method of extracting a product from biomass, the method comprising: introducing biomass into a process chamber; mechanically sealing the process chamber; mechanically compressing the biomass to release a first fluid material; mechanically decompressing the biomass; introducing an extraction solvent into the process chamber; maintaining process-chamber pressure from about 1 bar to about 1000 bar, wherein the extraction solvent extracts a second fluid material; and recovering the second fluid material from the process chamber. High processing throughput is enabled with this invention.

Some variations provide a system for extracting a product from biomass, comprising: a process chamber having an internal volume; one or more mechanical elements configured to controllably and reversibly mechanically seal the process chamber and reduce the internal volume to mechanically compress the biomass; a fluid port in flow communication with the process chamber; and a collection sub-system in flow communication with the fluid port. Other variations provide a method of extracting a product from biomass, the method comprising: introducing biomass into a process chamber; mechanically sealing the process chamber; mechanically compressing the biomass to release a first fluid material; mechanically decompressing the biomass; introducing an extraction solvent into the process chamber; maintaining process-chamber pressure from about 1 bar to about 1000 bar, wherein the extraction solvent extracts a second fluid material; and recovering the second fluid material from the process chamber. High processing throughput is enabled with this invention.

Systems and methods for the treatment of plants, including decarboxylation, photo-oxidation, oxidation and/or combinations thereof, of cannabis and hemp plants and oils for biosynthesizing THCA, CBDA, and CBCA from CBGA are disclosed. A cannabinoid compound solution is fed into a cavitation zone of a controlled cavitation apparatus where the cannabinoid compound solution is subjected to cavitation and interaction with UV light for conversion of the cannabinoid compound solution to form a synthesized cannabinoid THC, CBD, CBC, CBG, CBNA, CBEA, CBLA product, or combinations thereof.

Systems and methods for the treatment of plants, including decarboxylation, photo-oxidation, oxidation and/or combinations thereof, of cannabis and hemp plants and oils for biosynthesizing THCA, CBDA, and CBCA from CBGA are disclosed. A cannabinoid compound solution is fed into a cavitation zone of a controlled cavitation apparatus where the cannabinoid compound solution is subjected to cavitation and interaction with UV light for conversion of the cannabinoid compound solution to form a synthesized cannabinoid THC, CBD, CBC, CBG, CBNA, CBEA, CBLA product, or combinations thereof.

The formulation includes CBD and a PPAR agonist. The PPAR agonist can be an omega-3 based PPAR agonist and more specifically can comprise substantially equal parts DHA and EPA.

The present disclosure relates to water-soluble formulations containing cannabinoids. In particular, the formulations comprise at least one isolated cannabinoid, cannabinoid oil or cannabinoid resin, and a solubilizing agent of Formula (I), where the group X is a residue of a hydrophobic moiety selected from sterols, tocopherols, and derivatives thereof, and the group Y is a residue of a hydrophilic moiety selected from polyalcohols, polyethers, and derivatives thereof. In preferred embodiments, the cannabinoid comprises cannabidiol (CBD) or Δ9-tetrahydrocannabinol (THC) and the hydrophobic moiety is polyoxyethanyl-α-tocopheryl sebacate (TPS). In embodiments, the formulations comprise a carrier oil, such as a medium length triglyceride (MCT), and are dispersed in water in the form of micelles.

The present disclosure relates to isolating one or more cannabinoids from an input mixture. There is disclosed an apparatus that comprises a mixing vessel, a volatizing unit, and a distillation unit. The mixing vessel combines a first input mixture and a high boiling-point carrier agent to generate a second input mixture. The volatizing unit volatilizes cannabinoids from the second input mixture for separating the mixture into a cannabinoid-containing vapor stream and a residue. The distillation unit receives the cannabinoid-containing vapor stream and separates a first cannabinoid from at least a second cannabinoid. There are also disclosed methods that comprise the steps of combining a first input mixture with a high boiling-point carrier agent to provide a second input mixture, volatilizing the second input mixture into a vapor stream containing one or more cannabinoids and a residue, and separating a first cannabinoid from a second in the distillation unit.

The present disclosure relates to isolating one or more cannabinoids from an input mixture. There is disclosed an apparatus that comprises a mixing vessel, a volatizing unit, and a distillation unit. The mixing vessel combines a first input mixture and a high boiling-point carrier agent to generate a second input mixture. The volatizing unit volatilizes cannabinoids from the second input mixture for separating the mixture into a cannabinoid-containing vapor stream and a residue. The distillation unit receives the cannabinoid-containing vapor stream and separates a first cannabinoid from at least a second cannabinoid. There are also disclosed methods that comprise the steps of combining a first input mixture with a high boiling-point carrier agent to provide a second input mixture, volatilizing the second input mixture into a vapor stream containing one or more cannabinoids and a residue, and separating a first cannabinoid from a second in the distillation unit.