The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 respectively are important intermediates for a process for preparing the respective compounds 2a and 2b of the following formula 2, which are 2,2′-binaphthol-3-aldehyde derivatives. The following compounds 2a and 2b are useful for preparing enantiomerically pure amino acids. The present invention provides a method for preparing the above compounds 1a and 1b very conveniently and economically, and suitably for mass production. [formula 2]

The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 respectively are important intermediates for a process for preparing the respective compounds 2a and 2b of the following formula 2, which are 2,2′-binaphthol-3-aldehyde derivatives. The following compounds 2a and 2b are useful for preparing enantiomerically pure amino acids. The present invention provides a method for preparing the above compounds 1a and 1b very conveniently and economically, and suitably for mass production. [formula 2]

The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction. The method comprises the following steps: centrifuging the microbial fermentation broth or enzymatic conversion solution containing α-KG and PA to remove the cells and other visible solids; removing the macromolecular impurities by ultrafiltration; evaporating and concentrating under reduced pressure conditions; extracting with the water-insoluble extraction after acidification; separating crude crystals of α-KG and crude liquid of PA by evaporation crystallization method (if concentration of PA is great higher than that of α-KG, crystallization separation should be conducted after distilling partial pure pyruvate); washing the crude crystal of α-KG with water-insoluble organic solvent as ethyl acetate or butyl acetate, drying and crushing to obtain qualified α-KG; distilling to gain qualified PA product applying high vacuum distillation (or molecular distillation).

The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction. The method comprises the following steps: centrifuging the microbial fermentation broth or enzymatic conversion solution containing α-KG and PA to remove the cells and other visible solids; removing the macromolecular impurities by ultrafiltration; evaporating and concentrating under reduced pressure conditions; extracting with the water-insoluble extraction after acidification; separating crude crystals of α-KG and crude liquid of PA by evaporation crystallization method (if concentration of PA is great higher than that of α-KG, crystallization separation should be conducted after distilling partial pure pyruvate); washing the crude crystal of α-KG with water-insoluble organic solvent as ethyl acetate or butyl acetate, drying and crushing to obtain qualified α-KG; distilling to gain qualified PA product applying high vacuum distillation (or molecular distillation).

The present disclosure provides a method for extracting alpha-ketoglutarate and pyruvate simultaneously from microbial fermentation broth or enzyme transformation solution, which is related to the technical field of biological separation and extraction. The method comprises the following steps: centrifuging the microbial fermentation broth or enzymatic conversion solution containing α-KG and PA to remove the cells and other visible solids; removing the macromolecular impurities by ultrafiltration; evaporating and concentrating under reduced pressure conditions; extracting with the water-insoluble extraction after acidification; separating crude crystals of α-KG and crude liquid of PA by evaporation crystallization method (if concentration of PA is great higher than that of α-KG, crystallization separation should be conducted after distilling partial pure pyruvate); washing the crude crystal of α-KG with water-insoluble organic solvent as ethyl acetate or butyl acetate, drying and crushing to obtain qualified α-KG; distilling to gain qualified PA product applying high vacuum distillation (or molecular distillation).

The present invention relates to a method for producing a formic acid including, a first step of allowing carbon dioxide and hydrogen to react with each other in a solution containing a solvent and a catalyst dissolved in the solvent and in the presence of an amine insoluble in the solvent, and allowing a generated formic acid to adsorb to the amine, in which the catalyst contains at least one metal element selected from the group consisting of metal elements belonging to Groups 8, 9, and 10 of a periodic table and the amine is an amine immobilized on a solid.

The present invention relates to a method for producing a formic acid including, a first step of allowing carbon dioxide and hydrogen to react with each other in a solution containing a solvent and a catalyst dissolved in the solvent and in the presence of an amine insoluble in the solvent, and allowing a generated formic acid to adsorb to the amine, in which the catalyst contains at least one metal element selected from the group consisting of metal elements belonging to Groups 8, 9, and 10 of a periodic table and the amine is an amine immobilized on a solid.

A method for generating a carboxylic acid from carbon dioxide (CO.sub.2), the method includes (a) feeding a gas stream having the CO.sub.2 to a first reactor having a base (MOH) to produce bicarbonate (MHCO.sub.3) and (b) feeding the MHCO.sub.3 generated in the first reactor to a second reactor disposed downstream from the first reactor. The second reactor includes a catalyst. The method also includes (c) contacting the MHCO.sub.3 with hydrogen gas in the presence of the catalyst in the second reactor to produce formate (HCOOM) and (d) electrolysing an aqueous solution of a metal halide (MCl) in a chloro-alkali electrolysis reactor fluidly coupled to the first reactor, the second reactor, or both to produce at least a portion of the MOH, the hydrogen gas and Cl.sub.2. The portion of the MOH is used in step (a) and the carboxylic acid is formic acid (HCOOH).

A method for generating a carboxylic acid from carbon dioxide (CO.sub.2), the method includes (a) feeding a gas stream having the CO.sub.2 to a first reactor having a base (MOH) to produce bicarbonate (MHCO.sub.3) and (b) feeding the MHCO.sub.3 generated in the first reactor to a second reactor disposed downstream from the first reactor. The second reactor includes a catalyst. The method also includes (c) contacting the MHCO.sub.3 with hydrogen gas in the presence of the catalyst in the second reactor to produce formate (HCOOM) and (d) electrolysing an aqueous solution of a metal halide (MCl) in a chloro-alkali electrolysis reactor fluidly coupled to the first reactor, the second reactor, or both to produce at least a portion of the MOH, the hydrogen gas and Cl.sub.2. The portion of the MOH is used in step (a) and the carboxylic acid is formic acid (HCOOH).

A method for generating a carboxylic acid from carbon dioxide (CO.sub.2), the method includes (a) feeding a gas stream having the CO.sub.2 to a first reactor having a base (MOH) to produce bicarbonate (MHCO.sub.3) and (b) feeding the MHCO.sub.3 generated in the first reactor to a second reactor disposed downstream from the first reactor. The second reactor includes a catalyst. The method also includes (c) contacting the MHCO.sub.3 with hydrogen gas in the presence of the catalyst in the second reactor to produce formate (HCOOM) and (d) electrolysing an aqueous solution of a metal halide (MCl) in a chloro-alkali electrolysis reactor fluidly coupled to the first reactor, the second reactor, or both to produce at least a portion of the MOH, the hydrogen gas and Cl.sub.2. The portion of the MOH is used in step (a) and the carboxylic acid is formic acid (HCOOH).