The present application provides a method for synthesis of Roxadustat. A compound as represented by formula (VIII) is used as a raw material, and is reacted with phenol, a vinyl-containing ether, an acid, hydroxylamine, and then the product is reacted with glycine. In addition, the present application also provides intermediate compounds as represented by formula (IX), formula (XI), formula (XII), formula (IV), and formula (V) for synthesis of Roxadustat. Herein, details of the substituents involved in formula (VIII), formula (IX), formula (XI), and formula (XII) are stated in the description ##STR00001##

The present application provides a method for synthesis of Roxadustat. A compound as represented by formula (VIII) is used as a raw material, and is reacted with phenol, a vinyl-containing ether, an acid, hydroxylamine, and then the product is reacted with glycine. In addition, the present application also provides intermediate compounds as represented by formula (IX), formula (XI), formula (XII), formula (IV), and formula (V) for synthesis of Roxadustat. Herein, details of the substituents involved in formula (VIII), formula (IX), formula (XI), and formula (XII) are stated in the description ##STR00001##

##STR00001##

Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R.sup.1.Math.R.sup.4, m and n are as defined in the disclosure.

##STR00001##

Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R.sup.1.Math.R.sup.4, m and n are as defined in the disclosure.

Systems and methods for recycling polymers are provided. One embodiment provides a method for recycling synthetic polymers by combining the polymers with a solid depolymerizing catalyst in a vessel, mechanically shearing the combined polymers and the solid depolymerizing catalyst against each other to produce monomers from the polymers; and collecting the monomers. In some embodiments the solid depolymerizing catalyst is solid sodium hydroxide. In some embodiments collecting the monomers is achieved by contacting the sheared polymer and catalyst with a recyclable volatile solvent to dissolve the monomers. In some embodiments, the method includes purifying the collected monomers for repolymerization. In some embodiments purifying the monomers is achieved using nanofiltration membrane technology, cyclic fixed bed adsorption, simulated moving-bed adsorption or a combination thereof.

Systems and methods for recycling polymers are provided. One embodiment provides a method for recycling synthetic polymers by combining the polymers with a solid depolymerizing catalyst in a vessel, mechanically shearing the combined polymers and the solid depolymerizing catalyst against each other to produce monomers from the polymers; and collecting the monomers. In some embodiments the solid depolymerizing catalyst is solid sodium hydroxide. In some embodiments collecting the monomers is achieved by contacting the sheared polymer and catalyst with a recyclable volatile solvent to dissolve the monomers. In some embodiments, the method includes purifying the collected monomers for repolymerization. In some embodiments purifying the monomers is achieved using nanofiltration membrane technology, cyclic fixed bed adsorption, simulated moving-bed adsorption or a combination thereof.

The present invention relates to a method for production of terephthalic acid using high polymerization degree polyethylene terephthalate, which includes: (i) introducing high polymerization degree polyethylene terephthalate having an intrinsic viscosity of 0.75 dl/g or more into a continuous reactor, and then heating and pressurizing the same to prepare a fluidal polyethylene terephthalate; (ii) introducing a mixed slurry prepared by mixing an alkaline material containing an alkali-metal, a weak acid salt of the alkali-metal and ethylene glycol together into an internal position of the continuous reactor, through which the fluidal polyethylene terephthalate passes, and implementing neat reaction of the fluidal polyethylene terephthalate with the mixed slurry in the continuous reactor to prepare alkali-metal terephthalate; and (iii) dissolving the prepared alkali-metal terephthalate in water, removing foreign substances through filtration and centrifugation, adding acid to the alkali-metal terephthalate dissolved in water and reacting the same, thereby producing terephthalic acid.

The present invention relates to a method for production of terephthalic acid using high polymerization degree polyethylene terephthalate, which includes: (i) introducing high polymerization degree polyethylene terephthalate having an intrinsic viscosity of 0.75 dl/g or more into a continuous reactor, and then heating and pressurizing the same to prepare a fluidal polyethylene terephthalate; (ii) introducing a mixed slurry prepared by mixing an alkaline material containing an alkali-metal, a weak acid salt of the alkali-metal and ethylene glycol together into an internal position of the continuous reactor, through which the fluidal polyethylene terephthalate passes, and implementing neat reaction of the fluidal polyethylene terephthalate with the mixed slurry in the continuous reactor to prepare alkali-metal terephthalate; and (iii) dissolving the prepared alkali-metal terephthalate in water, removing foreign substances through filtration and centrifugation, adding acid to the alkali-metal terephthalate dissolved in water and reacting the same, thereby producing terephthalic acid.

The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.

The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.