The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-tri-fluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.

Provided herein novel processes for preparing carotenoids, substantially pure carotenoids (such as substantially pure trans crocetin diesters and substantially pure trans sodium crocetinate), pharmaceutical compositions, and related methods of treatment and uses. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, ARDS, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, and using the aqueous solutions and pharmaceutical compositions are also provided.

The present invention provides a method of preparing oxalic acid (H.sub.2C.sub.2O.sub.4), the method at least comprising the steps of: (a) providing a metal formate (HCO.sub.2M) containing stream, wherein the metal (M) of the metal formate (HCO.sub.2M) is a monovalent metal selected from the group consisting of Li, Na, K, Cs, Rb and a mixture thereof; (b) heating the metal formate (HCO.sub.2M) containing stream thereby obtaining a metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream; (c) subjecting the metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream to electrodialysis, thereby obtaining at least oxalic acid (M.sub.2C.sub.2O.sub.4) and a metal hydroxide (MOH).

The present invention provides a method of preparing oxalic acid (H.sub.2C.sub.2O.sub.4), the method at least comprising the steps of: (a) providing a metal formate (HCO.sub.2M) containing stream, wherein the metal (M) of the metal formate (HCO.sub.2M) is a monovalent metal selected from the group consisting of Li, Na, K, Cs, Rb and a mixture thereof; (b) heating the metal formate (HCO.sub.2M) containing stream thereby obtaining a metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream; (c) subjecting the metal oxalate (M.sub.2C.sub.2O.sub.4) containing stream to electrodialysis, thereby obtaining at least oxalic acid (M.sub.2C.sub.2O.sub.4) and a metal hydroxide (MOH).

The present invention relates to molecular isotopic engineering. The present invention relates to a method or process for preparing a target compound of a statistically defined isotopic composition comprising the step of reacting one or more reactant compounds, wherein each reactant compound is of a statistically defined isotopic composition. The reactant compound is reacted in a chemical process or a biological process thereby generating an isotopic mass balance, or further, an isotopic fractionation to produce the target compound. The present invention also relates to a statistically defined isotopic composition of a target compound. The statistically defined isotopic composition comprises an internal marker, and can be used as, for example, a security feature, an identity indicator, or a purity indicator of the target compound.

The present invention relates to molecular isotopic engineering. The present invention relates to a method or process for preparing a target compound of a statistically defined isotopic composition comprising the step of reacting one or more reactant compounds, wherein each reactant compound is of a statistically defined isotopic composition. The reactant compound is reacted in a chemical process or a biological process thereby generating an isotopic mass balance, or further, an isotopic fractionation to produce the target compound. The present invention also relates to a statistically defined isotopic composition of a target compound. The statistically defined isotopic composition comprises an internal marker, and can be used as, for example, a security feature, an identity indicator, or a purity indicator of the target compound.

The present invention relates to molecular isotopic engineering. The present invention relates to a method or process for preparing a target compound of a statistically defined isotopic composition comprising the step of reacting one or more reactant compounds, wherein each reactant compound is of a statistically defined isotopic composition. The reactant compound is reacted in a chemical process or a biological process thereby generating an isotopic mass balance, or further, an isotopic fractionation to produce the target compound. The present invention also relates to a statistically defined isotopic composition of a target compound. The statistically defined isotopic composition comprises an internal marker, and can be used as, for example, a security feature, an identity indicator, or a purity indicator of the target compound.

The invention relates to a process for preparing a semi-aromatic polyamide from diamine and dicarboxylic acid, comprising steps of •(i) dosing a liquid diamine to an agitated powder comprising an aromatic dicarboxylic acid thereby forming a powder comprising a diamine/dicarboxylic acid salt (DD-salt), and •(ii) solid-state polymerizing the DD-salt to obtain the polyamide.

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.

A process is described for making acrylic acid from dextrose, which comprises fermenting dextrose; removing solids from the resulting fermentation broth; removing lactic acid from the clarified broth by extraction into an organic solvent; separating out the lactic acid-loaded organic solvent while recycling at least a portion of the remainder back to the fermentation step; reacting the lactic acid with ammonia to provide a dehydration feed comprising ammonium lactate while preferably recycling the organic solvent; carrying out a vapor phase dehydration of the ammonium lactate to produce a crude acrylic acid product; and purifying the crude acrylic acid by distillation followed by melt crystallization, chromatography or both melt crystallization and chromatography.