The invention relates to a method for the production of calcium dipropionate by a batch process in a single pressure-resistant reaction vessel. The reaction vessel is charged with calcium oxide, calcium hydroxide, calcium carbonate or a mixture thereof. Then, pure high-concentrated propionic acid, preferably in a concentration of above 99% is added to the solid raw materials. The heat (up to 160 C.) and pressure (up to 10 bar) are retained in the reaction vessel and are subsequently used to discharge the reaction water after the complete amount of acid has been added. After a reaction time of 3 to 6 hours, pure calcium dipropionate with a water content of below 1% is obtained.

The invention relates to a method for the production of calcium dipropionate by a batch process in a single pressure-resistant reaction vessel. The reaction vessel is charged with calcium oxide, calcium hydroxide, calcium carbonate or a mixture thereof. Then, pure high-concentrated propionic acid, preferably in a concentration of above 99% is added to the solid raw materials. The heat (up to 160 C.) and pressure (up to 10 bar) are retained in the reaction vessel and are subsequently used to discharge the reaction water after the complete amount of acid has been added. After a reaction time of 3 to 6 hours, pure calcium dipropionate with a water content of below 1% is obtained.

The invention relates to a process for separation of organic acids from mixture of ammonium salts of one or more organic acids and other compounds via an integrated process. The process involves suspending mixture of ammonium salts of one or more organic acids and other compounds in dry hydrocarbon solvent/s or mixtures thereof; wherein the selected hydrocarbon solvent/s or mixtures thereof have boiling point more than 100 C. and forms an azeotrope with water. The reaction mixture thus obtained is dehydrated azeotropically followed by esterification of basic salt of the organic acids by addition of alcohol in presence of metal or metal salt; thereafter the individual esters formed are separated by distillation and hydrolyzed to obtain corresponding organic acids having more than 98% purity.

The invention relates to a process for separation of organic acids from mixture of ammonium salts of one or more organic acids and other compounds via an integrated process. The process involves suspending mixture of ammonium salts of one or more organic acids and other compounds in dry hydrocarbon solvent/s or mixtures thereof; wherein the selected hydrocarbon solvent/s or mixtures thereof have boiling point more than 100 C. and forms an azeotrope with water. The reaction mixture thus obtained is dehydrated azeotropically followed by esterification of basic salt of the organic acids by addition of alcohol in presence of metal or metal salt; thereafter the individual esters formed are separated by distillation and hydrolyzed to obtain corresponding organic acids having more than 98% purity.

A solid compound prepared as a powder that exhibits good flowability and having a specific structure is provided. The solid compound contains a carrier carboxylic acid salt and a loaded carboxylic acid, wherein the pKa of the corresponding carboxylic acid of the carrier carboxylic acid is lower than or equal to the pKa of the loaded carboxylic. The loaded carboxylic acid is physisorbed within the structure of the carrier carboxylic acid salt, and wherein the water content of the solid compound is less than 2 equivalents of water relative to the carrier carboxylic acid. Processes and pharmaceutical compositions containing the solid compound are also provided.

Carboxylic acids are prepared by a one-step gas phase process comprising the step of contacting under halogen-free hydroxycarbonylation conditions an alkene, carbon monoxide, water, and a solid sulfide-containing catalyst.

Carboxylic acids are prepared by a one-step gas phase process comprising the step of contacting under halogen-free hydroxycarbonylation conditions an alkene, carbon monoxide, water, and a solid sulfide-containing catalyst.

Carboxylic acids are prepared by a one-step gas phase process comprising the step of contacting under halogen-free hydroxycarbonylation conditions an alkene, carbon monoxide, water, and a solid sulfide-containing catalyst.

A method for chromatographically separating propionic acid from a liquid feed mixture including propionic acid and a carbohydrate by passing the liquid feed mixture through a bed including a strong base anion exchange resin.

A method for chromatographically separating propionic acid from a liquid feed mixture including propionic acid and a carbohydrate by passing the liquid feed mixture through a bed including a strong base anion exchange resin.