This disclosure provides scalable methods of synthesizing highly pure substituted carboxylic acids. One or more embodiments of the present disclosure relate to methods of synthesizing 2,2-dimethylbutanoic acid.

Platinum complexes having ferrocene-diphosphine ligands for catalysis of the hydroxycarbonylation of ethylenically unsaturated compounds.

Platinum complexes having ferrocene-diphosphine ligands for catalysis of the hydroxycarbonylation of ethylenically unsaturated compounds.

A rubber-metal adhesion promoter characterized by including: a metal salt (1) of a carboxylic acid which is a metal salt of an aliphatic carboxylic acid having 2 to 25 carbon atoms and in which the metal is bismuth, copper, antimony, silver or niobium; or a compound (2) represented by the following general formula (A): [wherein Z represents a structure selected from the following formulae (z-1) to (z-4); M represents bismuth, copper, antimony, silver or niobium; (RCOO) represents a residue of an aliphatic carboxylic acid having 2 to 25 carbon atoms; and x represents the valence of M minus 1].

##STR00001##

A rubber-metal adhesion promoter characterized by including: a metal salt (1) of a carboxylic acid which is a metal salt of an aliphatic carboxylic acid having 2 to 25 carbon atoms and in which the metal is bismuth, copper, antimony, silver or niobium; or a compound (2) represented by the following general formula (A): [wherein Z represents a structure selected from the following formulae (z-1) to (z-4); M represents bismuth, copper, antimony, silver or niobium; (RCOO) represents a residue of an aliphatic carboxylic acid having 2 to 25 carbon atoms; and x represents the valence of M minus 1].

##STR00001##

The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.

The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.

Provided is a method for producing an ester of butyric acid from an acid mixture, comprising contacting an aqueous carboxylic acid mixture comprising butyric acid and at least one additional carboxylic acid selected from the group consisting of formic acid, acetic acid, propionic acid, lactic acid, hydroxybutyric acid and combinations thereof, wherein at least 30% of the total amount of acids in the aqueous carboxylic acid mixture are in free acid form, with a liquid extractant having a Hildebrand solubility parameter of less than 25 MPa.sup.(1/2); separating a resultant butyric acid-comprising extract from a residual aqueous phase; contacting a resultant separated butyric acid-comprising extract with an alkanol in the presence of an acid catalyst, to form a product comprising an ester of butyric acid and alkanol and optionally water; wherein when water is formed, separating water to provide a separated product comprising an ester of butyric acid.

Provided is a method for producing an ester of butyric acid from an acid mixture, comprising contacting an aqueous carboxylic acid mixture comprising butyric acid and at least one additional carboxylic acid selected from the group consisting of formic acid, acetic acid, propionic acid, lactic acid, hydroxybutyric acid and combinations thereof, wherein at least 30% of the total amount of acids in the aqueous carboxylic acid mixture are in free acid form, with a liquid extractant having a Hildebrand solubility parameter of less than 25 MPa.sup.(1/2); separating a resultant butyric acid-comprising extract from a residual aqueous phase; contacting a resultant separated butyric acid-comprising extract with an alkanol in the presence of an acid catalyst, to form a product comprising an ester of butyric acid and alkanol and optionally water; wherein when water is formed, separating water to provide a separated product comprising an ester of butyric acid.

The subject invention relates to a process of preparing (R)-3-hydroxybutyric acid or a salt thereof by one-step fermentation with a nonpathogenic microorganism. The fermentation of (R)-3-hydroxybutyric acid was performed by supplying with certain carbon and nitrogen sources. These microorganisms include a Glutamic acid Bacterium HR057 strain or one type of genetically engineered Corynebacterium Glutamicum.