This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.

The present disclosure provides a method for isolating a long chain dicarboxylic acid from fermentation broth containing microbial cells. Also provided is a substantially pure long chain dicarboxylic acid isolated by the method.

The present disclosure provides a method for isolating a long chain dicarboxylic acid from fermentation broth containing microbial cells. Also provided is a substantially pure long chain dicarboxylic acid isolated by the method.

This invention relates to an improved hydrolysis process for the preparation of dicarboxylic acids in which an organic phase comprising triglycerides of carboxylic acids having more than one acid functional group and a mixture comprising dicarboxylic acids, glycerine and partial esters of glycerine are mixed with water and hydrolysed at temperatures of between 50 and 350 C., and at pressures of or above the equilibrium vapor pressure. This process makes it possible to obtain high hydrolysis yields, even in short times.

This invention relates to an improved hydrolysis process for the preparation of dicarboxylic acids in which an organic phase comprising triglycerides of carboxylic acids having more than one acid functional group and a mixture comprising dicarboxylic acids, glycerine and partial esters of glycerine are mixed with water and hydrolysed at temperatures of between 50 and 350 C., and at pressures of or above the equilibrium vapor pressure. This process makes it possible to obtain high hydrolysis yields, even in short times.

A novel branched fluorine-containing compound represented by formula (1):

(RfY.sub.n1LX-A).sub.n2(1)

wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; R.sup.Y, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents ArSO.sub.3M or the like; M, in each occurrence, is the same or different and represents hydrogen, NR.sub.4, or a metal salt; and R represents hydrogen or a C.sub.1-4 organic group.

A novel branched fluorine-containing compound represented by formula (1):

(RfY.sub.n1LX-A).sub.n2(1)

wherein L represents a predetermined carbon-containing linker moiety; Rf, in each occurrence, is the same or different and represents fluoroalkyl optionally having at least one ether bond; Y, in each occurrence, is the same or different and represents a predetermined divalent linking group or a bond; R.sup.Y, in each occurrence, is the same or different and represents hydrogen or an organic group; L represents an (n1+n2)-valent carbon-containing linker moiety having at least one carbon atom; n1 represents a number greater than or equal to 1; n2 represents a number greater than or equal to 1; n1+n2 is a number from 3 to 6; X, in each occurrence, is the same or different and represents a divalent linking group or a bond; A, in each occurrence, is the same or different and represents ArSO.sub.3M or the like; M, in each occurrence, is the same or different and represents hydrogen, NR.sub.4, or a metal salt; and R represents hydrogen or a C.sub.1-4 organic group.

A particulate, urea-containing composition and use of an additive for producing a particulate, urea-containing composition and methods of producing a particulate, urea-containing composition.

A method of forming transparent electrodes using printable conductive ink containing conductive materials dispersed in a viscous liquid which upon printing and thermal treatment will vaporise fully leaving behind the conductive material only. The viscous liquid acts as a medium by which conductive material dispersions are made processable for use in various printing techniques, allowing conductive patterns to be printed onto substrates (e.g. plastics, glass, metals, ceramics).