The present disclosure encompasses solid state forms of Setogepram, in embodiments crystalline polymorphs or salts of Setogepram, particularly Setogepram sodium, processes for preparation thereof, and pharmaceutical compositions thereof.

The present disclosure encompasses solid state forms of Setogepram, in embodiments crystalline polymorphs or salts of Setogepram, particularly Setogepram sodium, processes for preparation thereof, and pharmaceutical compositions thereof.

The present invention relates to novel herbicidally active 3-(2-bromo-4-alkynyl-6-alkoxyphenyl)-substituted pyrrolin-2-ones of the general formula (I) or agrochemically acceptable salts thereof and to their use for controlling broad-leaved weeds and weed grasses in crops of useful plants.

Described herein are valuable new chemical intermediates for producing perfuming ingredients, and a process for producing compound of formula (I).

Described herein are valuable new chemical intermediates for producing perfuming ingredients, and a process for producing compound of formula (I).

The present invention provides a compound represented by General Formula (1) or (1′) [in the formula, R.sup.1 and R.sup.2 each independently represents a hydrogen atom or a hydroxy group; R.sup.3 represents an alkyl group having 1 to 6 carbon atoms; R.sup.4 represents a halogen atom or an alkyl group; m indicates the number of R.sup.4 and represents an integer of 0 to 4; in a case where m is 2 or more, a plurality of R.sup.4's may be the same or different from each other; n represents an integer of 1 to 6; and n′ represents an integer of 1 to 4] and a neutrophil infiltration suppressor containing the compound as an active ingredient.

##STR00001##

The present invention provides a compound represented by General Formula (1) or (1′) [in the formula, R.sup.1 and R.sup.2 each independently represents a hydrogen atom or a hydroxy group; R.sup.3 represents an alkyl group having 1 to 6 carbon atoms; R.sup.4 represents a halogen atom or an alkyl group; m indicates the number of R.sup.4 and represents an integer of 0 to 4; in a case where m is 2 or more, a plurality of R.sup.4's may be the same or different from each other; n represents an integer of 1 to 6; and n′ represents an integer of 1 to 4] and a neutrophil infiltration suppressor containing the compound as an active ingredient.

##STR00001##

The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.

A strengthening oxidation system of the external micro-interfacial unit for producing PTA with PX is provided, including: a reactor, a circulating heat exchange device and a micro-interfacial unit. The reactor includes an outer casing and an inner cylinder disposed concentrically inside the outer casing. The circulating heat exchange device is disposed at an exterior of the reactor, and is connected with the outer casing and the inner cylinder respectively, for regulating reaction temperatures of the first reaction zone, the second reaction zone and the third reaction zone inside the reactor in a reaction process of producing PTA with PX. the micro-interfacial unit is connected between the reactor and the circulating heat exchange device, and connected with an external feed pipe of the reactor, for crushing a gas phase material into micro bubbles with a diameter greater than or equal to 1 μm and less than 1 mm and for mixing the micro bubbles with a liquid phase material to form an emulsion at the exterior of the reactor before a reaction material enters each of the reaction zones inside the reactor.

A strengthening oxidation system of the external micro-interfacial unit for producing PTA with PX is provided, including: a reactor, a circulating heat exchange device and a micro-interfacial unit. The reactor includes an outer casing and an inner cylinder disposed concentrically inside the outer casing. The circulating heat exchange device is disposed at an exterior of the reactor, and is connected with the outer casing and the inner cylinder respectively, for regulating reaction temperatures of the first reaction zone, the second reaction zone and the third reaction zone inside the reactor in a reaction process of producing PTA with PX. the micro-interfacial unit is connected between the reactor and the circulating heat exchange device, and connected with an external feed pipe of the reactor, for crushing a gas phase material into micro bubbles with a diameter greater than or equal to 1 μm and less than 1 mm and for mixing the micro bubbles with a liquid phase material to form an emulsion at the exterior of the reactor before a reaction material enters each of the reaction zones inside the reactor.