The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.

##STR00001##

The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.

##STR00001##

A compound with anti-drug resistant bacteria activity having the following formula ##STR00001##
is disclosed. A method of preparing the compound of formula (I) is also disclosed.

A compound with anti-drug resistant bacteria activity having the following formula ##STR00001##
is disclosed. A method of preparing the compound of formula (I) is also disclosed.

We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV):

##STR00001##

wherein R.sup.1 is hydrogen or substituted or unsubstituted alkyl,
characterized by reacting a compound represented by Formula (V):

##STR00002##

with a compound represented by Formula (VI):

##STR00003##

wherein R.sup.1 has the same meaning as defined above,
in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and/or a substituted or unsubstituted phenol.

We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV):

##STR00001##

wherein R.sup.1 is hydrogen or substituted or unsubstituted alkyl,
characterized by reacting a compound represented by Formula (V):

##STR00002##

with a compound represented by Formula (VI):

##STR00003##

wherein R.sup.1 has the same meaning as defined above,
in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and/or a substituted or unsubstituted phenol.

We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV):

##STR00001##

wherein R.sup.1 is hydrogen or substituted or unsubstituted alkyl,
characterized by reacting a compound represented by Formula (V):

##STR00002##

with a compound represented by Formula (VI):

##STR00003##

wherein R.sup.1 has the same meaning as defined above,
in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and/or a substituted or unsubstituted phenol.

Methods for the synthesis of a tricyclic-prostaglandin D.sub.2 metabolite methyl ester or a pharmaceutically acceptable salt thereof.

Methods for the synthesis of a tricyclic-prostaglandin D.sub.2 metabolite methyl ester or a pharmaceutically acceptable salt thereof.

Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C.sub.1-5 alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds. Moreover, it has been confirmed by means of performing pharmacological experiments on rats suffering from experimentally mixed hyperlipidemia that the emodin succinyl ester compound of the present invention is superior to emodin, and has the advantages of having a remarkable blood fat lowering effect, being safe, being simple and convenient to administer, the raw materials being low cost and readily available, and being easy to transport and store.